RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …

Efficient viral gene expression is threatened by cellular stress response programmes that
rapidly reprioritize the translation machinery in response to varied environmental assaults …

Eukaryotic cells express a family of eukaryotic translation initiation factor 2 alpha (eIF2α)
kinases (eg, PKR, PERK-PEK, GCN2, HRI) that are individually activated in response to …

RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …

▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the …

Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of
gene control in humans. It provides cells with the opportunity to create protein isoforms of …

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease
and is characterized by the degeneration of upper and lower motor neurons. It has become …

In violation of the'one gene, one polypeptide'rule, alternative splicing allows individual
genes to produce multiple protein isoforms—thereby playing a central part in generating …

TIA-1 is an RNA binding protein that promotes the assembly of stress granules (SGs),
discrete cytoplasmic inclusions into which stalled translation initiation complexes are …

Mammalian stress granules (SGs) are cytoplasmic domains into which mRNAs are sorted
dynamically in response to phosphorylation of eukaryotic initiation factor (eIF) 2α, a key …