G protein-coupled receptors (GPCRs) are the largest group of cell surface receptors in
humans that signal in response to diverse inputs and regulate a plethora of cellular …

The immune system plays a major role in the surveillance and control of malignant cells,
with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient …

To study integral membrane proteins, one has to extract them from the membrane—the step
that is typically achieved by the application of detergents. In this mini-review, we summarize …

The brain contains a fairly low amount of glycogen, mostly located in astrocytes, a fact that
has prompted the suggestion that glycogen does not have a significant physiological role in …

Neural circuit assembly in the brain requires precise establishment of synaptic connections,
but the mechanisms of synapse assembly remain incompletely understood. Latrophilins are …

G protein-coupled receptors are a major class of membrane receptors that mediate
physiological and pathophysiological cellular signaling. Many aspects of receptor activation …

Cannabinoid receptor 2 (CB2) is a promising therapeutic target for immunological
modulation. There is, however, a deficit of knowledge regarding CB2 signaling and function …

During the last two decades, melatonin has been found to have pleiotropic effects via
different mechanisms on its target cells. Data are abundant for some aspects of the signaling …

G protein-coupled receptors (GPCRs) are organised within the cell membrane into highly
ordered macromolecular complexes along with other receptors and signalling proteins …

Proper signaling by G protein coupled receptors (GPCR) is dependent on the specific
repertoire of transducing, enzymatic and regulatory kinases and phosphatases that shape its …