[HTML][HTML] Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain
M Miranda, JF Morici, MB Zanoni… - Frontiers in cellular …, 2019 - frontiersin.org
Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes
related to learning and memory. The expression of BDNF is highly regulated, and can lead …
related to learning and memory. The expression of BDNF is highly regulated, and can lead …
Activity-regulated transcription: bridging the gap between neural activity and behavior
EL Yap, ME Greenberg - Neuron, 2018 - cell.com
Gene transcription is the process by which the genetic codes of organisms are read and
interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …
interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …
TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders
M Notaras, M van den Buuse - Molecular psychiatry, 2020 - nature.com
Brain-derived neurotrophic factor (BDNF) is widely accepted for its involvement in resilience
and antidepressant drug action, is a common genetic locus of risk for mental illnesses, and …
and antidepressant drug action, is a common genetic locus of risk for mental illnesses, and …
Physical exercise as an epigenetic modulator of brain plasticity and cognition
J Fernandes, RM Arida, F Gomez-Pinilla - Neuroscience & Biobehavioral …, 2017 - Elsevier
A large amount of evidence has demonstrated the power of exercise to support cognitive
function, the effects of which can last for considerable time. An emerging line of scientific …
function, the effects of which can last for considerable time. An emerging line of scientific …
DNA methylation and its basic function
LD Moore, T Le, G Fan - Neuropsychopharmacology, 2013 - nature.com
In the mammalian genome, DNA methylation is an epigenetic mechanism involving the
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …
Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential
The immediate and long-term effects of exposure to early life stress (ELS) have been
documented in humans and animal models. Even relatively brief periods of stress during the …
documented in humans and animal models. Even relatively brief periods of stress during the …
Histone acetylation: molecular mnemonics on the chromatin
Long-lasting memories require specific gene expression programmes that are, in part,
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …
Potential therapeutic uses of BDNF in neurological and psychiatric disorders
AH Nagahara, MH Tuszynski - Nature reviews Drug discovery, 2011 - nature.com
The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-
related kinase receptor type B (TRKB) are actively produced and trafficked in multiple …
related kinase receptor type B (TRKB) are actively produced and trafficked in multiple …
Epigenetics and the biological definition of gene× environment interactions
MJ Meaney - Child development, 2010 - Wiley Online Library
Variations in phenotype reflect the influence of environmental conditions during
development on cellular functions, including that of the genome. The recent integration of …
development on cellular functions, including that of the genome. The recent integration of …