Recent insights on anti-dengue virus (DENV) medicinal plants: review on in vitro, in vivo and in silico discoveries

SYM Lim, JY Chieng, Y Pan - All Life, 2021 - Taylor & Francis
Dengue has become a global affliction despite continuous efforts to find cure for this age-old
disease. Hopeful results for dengue vaccine are far-fetched as the effectiveness are tied to …

High-content screening of Thai medicinal plants reveals Boesenbergia rotunda extract and its component Panduratin A as anti-SARS-CoV-2 agents

P Kanjanasirirat, A Suksatu, S Manopwisedjaroen… - Scientific reports, 2020 - nature.com
Since December 2019, the emergence of severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) has caused severe pneumonia, a disease named COVID-19, that became …

The current landscape of bioactive molecules against DENV: A systematic review

R Babbar, R Kaur, P Rana, S Arora… - Evidence‐Based …, 2023 - Wiley Online Library
With a 30‐fold increase in incidence over the previous 50 years, dengue fever is now the
most widespread viral disease transmitted by mosquitoes in the world. The intricate …

Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling

M Hariono, SB Choi, RF Roslim, MS Nawi, ML Tan… - PLoS …, 2019 - journals.plos.org
Dengue virus Type 2 (DENV-2) is predominant serotype causing major dengue epidemics.
There are a number of studies carried out to find its effective antiviral, however to date, there …

Fragment-based design of α-cyanoacrylates and α-cyanoacrylamides targeting Dengue and Zika NS2B/NS3 proteases

GG Vilela, WF dos Santos Silva… - New Journal of …, 2022 - pubs.rsc.org
Viruses belonging to the Flaviviridae family account for millions of cases of infections
worldwide, mainly Dengue (DENV) and Zika (ZIKV) viruses. Both mosquito-borne …

Interaction of panduratin A and derivatives with the SARS-CoV-2 main protease (mpro): a molecular docking study

G Vergoten, C Bailly - Journal of Biomolecular Structure and …, 2023 - Taylor & Francis
Abstract Panduratin A (Pa-A) is a prenylated cyclohexenyl chalcone isolated from the
rhizomes of the medicinal and culinary plant Boesenbergia rotunda (L.) Mansf., commonly …

The identification of active compounds in Ganoderma lucidum var. antler extract inhibiting dengue virus serine protease and its computational studies

WZ Lim, PG Cheng, AY Abdulrahman… - Journal of Biomolecular …, 2020 - Taylor & Francis
The number of global dengue incidences is alarmingly high in recent years. The global
distribution of four dengue serotypes has also added economic burden in the dengue …

[HTML][HTML] Inhibitory effect of Sinapic acid derivatives targeting structural and non-structural proteins of dengue virus serotype 2: An in-silico assessment

M Roney, A Dubey, NB Zamri, MFFM Aluwi - Aspects of Molecular …, 2023 - Elsevier
Abstract DENV infects 50–100 million individuals, and 500,000 of them go on to acquire the
more serious dengue hemorrhagic fever, which causes around 20,000 fatalities every year …

New binding site conformations of the dengue virus NS3 protease accessed by molecular dynamics simulation

H de Almeida, IMD Bastos, BM Ribeiro, B Maigret… - PloS one, 2013 - journals.plos.org
Dengue fever is caused by four distinct serotypes of the dengue virus (DENV1-4), and is
estimated to affect over 500 million people every year. Presently, there are no vaccines or …

Current approaches in antiviral drug discovery against the Flaviviridae family

A Baharuddin, A Amir Hassan… - Current …, 2014 - ingentaconnect.com
Viruses belonging to the Flaviviridae family primarily spread through arthropod vectors, and
are the major causes of illness and death around the globe. The Flaviviridae family consists …