[PDF][PDF] HIGH-DIMENSIONAL ASYMPTOTIC BEHAVIOR OF INFERENCE BASED ON GWAS SUMMARY STATISTIC.

J Jiang, W Jiang, D Paul, Y Zhang, H Zhao - Statistica Sinica, 2023 - drive.google.com
We study the high-dimensional asymptotic behavior of inferences based on summary
statistics that are widely used in genome-wide association studies (GWAS) under model …

Estimating trans-ancestry genetic correlation with unbalanced data resources

B Zhao, X Yang, H Zhu - Journal of the American Statistical …, 2024 - Taylor & Francis
The aim of this article is to propose a novel method for estimating trans-ancestry genetic
correlations in genome-wide association studies (GWAS) using genetically predicted …

Estimation of the genetic Gaussian network using GWAS summary data

Y Yang, N Lorincz-Comi, X Zhu - arXiv preprint arXiv:2401.07767, 2024 - arxiv.org
Genetic Gaussian network of multiple phenotypes constructed through the genetic
correlation matrix is informative for understanding their biological dependencies. However …

High-dimensional statistical inference for linkage disequilibrium score regression and its cross-ancestry extensions

F Xue, B Zhao - arXiv preprint arXiv:2306.15779, 2023 - arxiv.org
Linkage disequilibrium score regression (LDSC) has emerged as an essential tool for
genetic and genomic analyses of complex traits, utilizing high-dimensional data derived …

Heritability estimation for a linear combination of phenotypes via ridge regression

X Li, X Feng, X Liu - Bioinformatics, 2022 - academic.oup.com
Motivation The joint analysis of multiple phenotypes is important in many biological studies,
such as plant and animal breeding. The heritability estimation for a linear combination of …

A novel framework for online supervised learning with feature selection

L Sun, M Wang, S Zhu, A Barbu - Journal of Nonparametric …, 2024 - Taylor & Francis
Current online learning methods suffer issues such as lower convergence rates and limited
capability to select important features compared to their offline counterparts. In this paper, a …

A Regression-based Approach to Robust Estimation and Inference for Genetic Covariance

J Wang, S Li, H Li - Journal of the American Statistical Association, 2023 - Taylor & Francis
Genome-wide association studies (GWAS) have identified thousands of genetic variants
associated with complex traits, and some variants are shown to be associated with multiple …

Inference of Shared Genetic Architecture with Genome-Wide Association Data

J Wang - 2022 - search.proquest.com
Genome-wide association studies (GWAS) have identified thousands of genetic variants
associated with complex traits. Many complex traits and diseases share common genetic …