Safety by design: Biosafety and biosecurity in the age of synthetic genomics

SA Hoffmann, J Diggans, D Densmore, J Dai, T Knight… - Iscience, 2023 - cell.com
Technologies to profoundly engineer biology are becoming increasingly affordable,
powerful, and accessible to a widening group of actors. While offering tremendous potential …

The need for adaptability in detection, characterization, and attribution of biosecurity threats

W Mo, CA Vaiana, CJ Myers - Nature Communications, 2024 - nature.com
Modern biotechnology necessitates robust biosecurity protocols to address the risk of
engineered biological threats. Current efforts focus on screening DNA and rejecting the …

SeqScreen: accurate and sensitive functional screening of pathogenic sequences via ensemble learning

A Balaji, B Kille, AD Kappell, GD Godbold, M Diep… - Genome biology, 2022 - Springer
The COVID-19 pandemic has emphasized the importance of accurate detection of known
and emerging pathogens. However, robust characterization of pathogenic sequences …

PlasmidHawk improves lab of origin prediction of engineered plasmids using sequence alignment

Q Wang, B Kille, TR Liu, RAL Elworth… - Nature …, 2021 - nature.com
With advances in synthetic biology and genome engineering comes a heightened
awareness of potential misuse related to biosafety concerns. A recent study employed …

Addressing biohazards to food security in primary production

A Djurle, B Young, A Berlin, I Vågsholm, AL Blomström… - Food Security, 2022 - Springer
This review addresses ways to prepare for and to mitigate effects of biohazards on primary
production of crops and livestock. These biohazards can be natural or intentional …

Leveraging Large Language Models for Predicting Microbial Virulence from Protein Structure and Sequence

F Quintana, T Treangen, L Kavraki - Proceedings of the 14th ACM …, 2023 - dl.acm.org
In the aftermath of COVID-19, screening for pathogens has never been a more relevant
problem. However, computational screening for pathogens is challenging due to a variety of …

Cyberbiosecurity: DNA injection attack in synthetic biology

D Farbiash, R Puzis - arXiv preprint arXiv:2011.14224, 2020 - arxiv.org
Today arbitrary synthetic DNA can be ordered online and delivered within several days. In
order to regulate both intentional and unintentional generation of dangerous substances …

Screening State of Play: The Biosecurity Practices of Synthetic DNA Providers

A Kane, MT Parker - Applied Biosafety, 2024 - liebertpub.com
Introduction: Synthetic DNA technology is rapidly emerging as a key driver of innovation in
the fields of medicine, biotechnology, and more. But it also poses significant risk, particularly …

Establishing an incentive-based multistakeholder approach to dual-use DNA screening

CR Isaac - Biochemistry and Cell Biology, 2022 - cdnsciencepub.com
Fast, accessible, and high-quality deoxyribonucleic acid (DNA) is fundamental to
advancement in the life sciences that will drive forward fields such as agriculture, energy …

[PDF][PDF] State of the art of Synthetic Biology-Literature Review

TB Johansen, EH Madslien - 2024 - fhi.brage.unit.no
Executive summary This review explores recent technological advancements in synthetic
biology. Developments within this field bring a wealth of potential benefits to multiple …