Leishmania is an obligate intracellular pathogen that invades phagocytic host cells.
Approximately 30 different species of Phlebotomine sand flies can transmit this parasite …

Abstract Liposomal amphotericin B (AmBisome®; LAmB) is a unique lipid formulation of
amphotericin B. LAmB is a standard of care for a wide range of medically important …

In this study, the antifungal effects of silver nano-particles (nano-Ag) and their mode of action
were investigated. Nano-Ag showed antifungal effects on fungi tested with low hemolytic …

Magainin peptides, isolated from Xenopus skin, have broad spectra of antimicrobial activity
and low toxicities to normal eukaryotic cells, thus being good candidates for therapeutic …

The fungal cell wall is a critically important structure that represents a permeability barrier
and protective shield. We probed Candida albicans and Cryptococcus neoformans with …

Amphotericin B is the treatment of choice for life-threatening systemic fungal infections such
as candidosis and aspergillosis. To improve this drug's efficacy and reduce its acute and …

Amphotericin B is a low-soluble polyene antibiotic which is able to self-aggregate. The
aggregation state can modify its activity and pharmacokinetical characteristics. In spite of its …

In the past decade substantial progress has been made in understanding the organization
and biological activity of amphotericin B (AmB) in the presence of sterols in lipid …

A growing number of reports suggest that elevated levels of extracellular Alzheimer's β-
amyloid protein alter the homeostasis of free [Ca 2+] i in different cell types of the …

The polarization of sterol-and sphingolipid-enriched domains (lipid rafts) has been linked to
morphogenesis and cell movement in diverse cell types. In the yeast Saccharomyces …