Protein dynamics play a crucial role in biological function, encompassing motions ranging
from atomic vibrations to large-scale conformational changes. Recent advancements in …

Characterizing the structures, interactions, and dynamics of molecules in their native liquid
state is a long-existing challenge in chemistry, molecular science, and biophysics with …

Phosphorylated residues of G protein-coupled receptors bind to the N-domain of arrestin,
resulting in the release of its C-terminus. This induces further allosteric conformational …

Single-particle cryo-electron microscopy has become a widely adopted method in structural
biology due to many recent technological advances in microscopes, detectors and image …

Gene expression is dependent on RNA Polymerase II (Pol II) activity in eukaryotes. In
addition to determining the rate of RNA synthesis for all protein coding genes, Pol II serves …

Microsecond time-resolved cryo-electron microscopy has emerged as a novel approach for
directly observing protein dynamics. By providing microsecond temporal and near-atomic …

Electron microscopy (EM) techniques have been crucial for understanding the structure of
biological specimens such as cells, tissues and macromolecular assemblies. Viruses and …

Solvent accessible surface area (SASA) of amino acid residues plays a significant role in
inter-residue, protein-ligand, and protein-protein interactions. Affecting the exposure and …

Protein dynamics play a crucial role in biological function, encompassing motions ranging
from atomic vibrations to large-scale conformational changes. Recent advancements in …

Proteins are macromolecular machines with roles in all cellular activities and structures. The
functional properties of each protein is the result of its combination of 3D-structure and …