In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal
viral infection. IFNs are secreted cytokines that activate a signal transduction cascade …

Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively,
they are highly effective at resisting and controlling pathogens. In this review, we begin by …

Many viruses trigger the type I interferon (IFN) system, leading to the transcription of
hundreds of interferon-stimulated genes (ISGs). The products of these ISGs exert numerous …

With recent improvements in the treatment of end‐stage liver disease (ESLD), a better
understanding of the burden of cirrhosis and hepatocellular carcinoma (HCC) is needed in …

Hepatitis C virus (HCV) is a global public health problem involving chronic infection of the
liver, which can cause liver disease and is linked with liver cancer. Viral innate immune …

The endoplasmic reticulum (ER) is an architecturally diverse organelle that serves as a
membrane source for the replication of multiple viruses. Flaviviruses, including yellow fever …

Summary Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor
reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that …

Interferons are a group of immunomodulatory substances produced by the human immune
system in response to the presence of pathogens, especially during viral and bacterial …

Hepatitis C virus (HCV) chronically infects 3% of the world's population, and complications
from HCV are the leading indication for liver transplantation. Given the need for better anti …

Although susceptibility of neurons in the brain to microbial infection is a major determinant of
clinical outcome, little is known about the molecular factors governing this vulnerability. Here …