The multifaceted role of reactive oxygen species in tumorigenesis

A Kirtonia, G Sethi, M Garg - Cellular and Molecular Life Sciences, 2020 - Springer
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

Arsenic exposure: A public health problem leading to several cancers

I Palma-Lara, M Martínez-Castillo… - Regulatory Toxicology …, 2020 - Elsevier
Arsenic, a metalloid and naturally occurring element, is one of the most abundant elements
in the earth's crust. Water is contaminated by arsenic through natural sources (underground …

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis

B Zhou, J Zhang, X Liu, H Chen, Y Ai, K Cheng, R Sun… - Cell research, 2018 - nature.com
Iron has been shown to trigger oxidative stress by elevating reactive oxygen species (ROS)
and to participate in different modes of cell death, such as ferroptosis, apoptosis and …

Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals

S Prasad, SC Gupta, AK Tyagi - Cancer letters, 2017 - Elsevier
Extensive research over the past half a century indicates that reactive oxygen species (ROS)
play an important role in cancer. Although low levels of ROS can be beneficial, excessive …

Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk

A Kumar, M Ali, R Kumar, M Kumar, P Sagar… - Scientific reports, 2021 - nature.com
Reportedly, 300 million people worldwide are affected by the consumption of arsenic
contaminated groundwater. India prominently figures amongst them and the state of Bihar …

Antioxidants from plants protect against skin photoaging

G Petruk, R Del Giudice, MM Rigano… - … medicine and cellular …, 2018 - Wiley Online Library
Exposure to UV light triggers the rapid generation and accumulation of reactive oxygen
species (ROS) in skin cells, with consequent increase in oxidative stress and thus in …

Reactive oxygen species in cancer

GY Liou, P Storz - Free radical research, 2010 - Taylor & Francis
Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers,
where they promote many aspects of tumour development and progression. However …

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease

EJ Seo, N Fischer, T Efferth - Pharmacological research, 2018 - Elsevier
Alzheimer's disease (AD) is the most prevalent form of dementia. The exact pathophysiology
of this disease remains incompletely understood and safe and effective therapies are …

Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy

SC Gupta, D Hevia, S Patchva, B Park… - Antioxidants & redox …, 2012 - liebertpub.com
Significance: Extensive research during the last quarter century has revealed that reactive
oxygen species (ROS) produced in the body, primarily by the mitochondria, play a major role …

Arsenic exposure and the induction of human cancers

VD Martinez, EA Vucic, DD Becker-Santos… - Journal of …, 2011 - Wiley Online Library
Arsenic is a metalloid, that is, considered to be a human carcinogen. Millions of individuals
worldwide are chronically exposed through drinking water, with consequences ranging from …