The Effect of Historical Data-Based Informative Prior on Benchmark Dose Estimation of Toxicogenomics
High-throughput toxicogenomics as an advanced toolbox of Tox21 plays an increasingly
important role in facilitating the toxicity assessment of environmental chemicals. However …
important role in facilitating the toxicity assessment of environmental chemicals. However …
An investigation of non-informative priors for Bayesian dose-response modeling
MW Wheeler - Regulatory Toxicology and Pharmacology, 2023 - Elsevier
Toxicology analyses are built around dose-response modeling, and increasingly these
methodologies utilize Bayesian estimation techniques. Bayesian estimation is unique …
methodologies utilize Bayesian estimation techniques. Bayesian estimation is unique …
Evaluating marginal likelihood approximations of dose-response relationship models in Bayesian benchmark dose methods for risk assessment
S Minewaki, T Ohigashi, T Sozu - arXiv preprint arXiv:2411.19066, 2024 - arxiv.org
Benchmark dose (BMD; a dose associated with a specified change in response) is used to
determine the point of departure for the acceptable daily intake of substances for humans …
determine the point of departure for the acceptable daily intake of substances for humans …
[PDF][PDF] 基于基准剂量方法的动物替代策略及其应用
邵侃 - 中国药理学与毒理学杂志, 2024 - cjpt.magtechjournal.com
剂量-反应评估作为风险评估中的关键定量步骤, 其作用是确定安全剂量水平.
与传统最大无害剂量方法相比, 基准剂量(BMD) 法促进了3R 原则(减少, 替代和优化) …
与传统最大无害剂量方法相比, 基准剂量(BMD) 法促进了3R 原则(减少, 替代和优化) …