Fatty acids as antibiofilm and antivirulence agents

P Kumar, JH Lee, H Beyenal, J Lee - Trends in microbiology, 2020 - cell.com
Fatty acids (FAs) have emerged as a potential alternative to conventional antibiotics. Since
many microbes respond differently to a variety of natural and synthetic FAs, substantial …

A review on biofilms and the currently available antibiofilm approaches: matrix-destabilizing hydrolases and anti-bacterial peptides as promising candidates for the …

M Akbarian, SH Chen, M Kianpour, F Farjadian… - International Journal of …, 2022 - Elsevier
Biofilms are communities of microorganisms that can be harmful and/or beneficial,
depending on location and cell content. Since in most cases (such as the formation of …

Antibiofilm and antifungal activities of medium‐chain fatty acids against Candida albicans via mimicking of the quorum‐sensing molecule farnesol

JH Lee, YG Kim, SK Khadke, J Lee - Microbial Biotechnology, 2021 - Wiley Online Library
Candida biofilms are tolerant to conventional antifungal therapeutics and the host immune
system. The transition of yeast cells to hyphae is considered a key step in C. albicans biofilm …

Characterization of the anti-biofilm and anti-quorum sensing activities of the β-adrenoreceptor antagonist atenolol against gram-negative bacterial pathogens

S Cavalu, SS Elbaramawi, AG Eissa… - International Journal of …, 2022 - mdpi.com
The development of bacterial resistance to antibiotics is an increasing public health issue
that worsens with the formation of biofilms. Quorum sensing (QS) orchestrates the bacterial …

Anti-Quorum Sensing Activities of Gliptins against Pseudomonas aeruginosa and Staphylococcus aureus

MT Khayat, HA Abbas, TS Ibrahim, AN Khayyat… - Biomedicines, 2022 - mdpi.com
The development of bacterial resistance to traditional antibiotics constitutes an emerging
public health issue. Promising approaches have been innovated to conquer bacterial …

Inhibition of Staphylococcus aureus biofilm formation and virulence factor production by petroselinic acid and other unsaturated C18 fatty acids

JH Lee, YG Kim, J Lee - Microbiology Spectrum, 2022 - Am Soc Microbiol
Staphylococcus aureus is a major human pathogen that secretes several toxins associated
with the pathogenesis of sepsis and pneumonia. Its antibiotic resistance is notorious, and its …

Sodium Citrate Alleviates Virulence in Pseudomonas aeruginosa

MT Khayat, TS Ibrahim, AN Khayyat, M Alharbi… - Microorganisms, 2022 - mdpi.com
The development of bacterial resistance is an insistent global health care issue, especially
in light of the dwindled supply of new antimicrobial agents. This mandates the development …

Diminishing the Pathogenesis of the Food-Borne Pathogen Serratia marcescens by Low Doses of Sodium Citrate

MT Khayat, SS Elbaramawi, SI Nazeih, MK Safo… - Biology, 2023 - mdpi.com
Simple Summary Sodium citrate is a safe and frequently used food additive; the objective of
this study is to assess the effectiveness of sodium citrate at low concentrations of 4% or 5 …

Xylitol Inhibits Growth and Blocks Virulence in Serratia marcescens

AN Khayyat, WAH Hegazy, MA Shaldam, R Mosbah… - Microorganisms, 2021 - mdpi.com
Serratia marcescens is an opportunistic nosocomial pathogen and causes wound and burn
infections. It shows high resistance to antibiotics and its pathogenicity is mediated by an …

Selective Antimicrobial Effects of Curcumin@Halloysite Nanoformulation: A Caenorhabditis elegans Study

G Fakhrullina, E Khakimova, F Akhatova… - … Applied Materials & …, 2019 - ACS Publications
Alterations in the normal gastrointestinal microbial community caused by unhealthy diet,
environmental factors, and antibiotic overuse may severely affect human health and well …