Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …

Acute kidney injury (AKI) is an increasing health burden with high morbidity and mortality
rates worldwide. AKI is a risk factor for chronic kidney disease (CKD) development and …

Chronic inflammation is postulated to be involved in the development of end-stage renal
disease in diabetes, but which specific circulating inflammatory proteins contribute to this …

Tissue injury and inflammatory response trigger the development of fibrosis in various
diseases. It has been recognized that both innate and adaptive immune cells are important …

Immune responses are dependent on the recruitment of leukocytes to the site of
inflammation. The classical leukocyte recruitment cascade, consisting of capture, rolling …

Systemic lupus erythematosus (SLE) is a disease characterized by dysregulation and
hyperreactivity of the immune response at various levels, including hyperactivation of …

The most classical view of the renin-angiotensin system (RAS) emphasizes its role as an
endocrine regulator of sodium balance and blood pressure. However, it has long become …

Hypertension is now considered as an inflammatory disease, and the kidney is a key end-
organ target. Experimental and clinical studies suggest that interleukin 17A (IL-17A) is a …

We hypothesized that the store-operated calcium entry (SOCE) channel, Orai1, participates
in the activation of Th17 cells and influences renal injury. In rats, following renal …

Over the past 20 years, there has been an increased appreciation of the long-term sequelae
of acute kidney injury (AKI) and the potential development of chronic kidney disease (CKD) …