The past decade has witnessed a paradigm shift in preclinical drug discovery with structure-
based drug design (SBDD) making a comeback while high-throughput screening (HTS) …

We present a series of databanks (http://swift. cmbi. ru. nl/gv/facilities/) that hold information
that is computationally derived from Protein Data Bank (PDB) entries and that might …

The most prevalent physiological effects of ANG II, the main product of the renin-angiotensin
system, are mediated by the AT1 receptor, a rhodopsin-like AGPCR. Numerous studies of …

Ten years of experience with molecular class–specific information systems (MCSIS) such as
with the hand‐curated G protein–coupled receptor database (GPCRDB) or the …

The GPCRDB is a Molecular Class-Specific Information System (MCSIS) that collects,
combines, validates and disseminates large amounts of heterogeneous data on G protein …

A statistical approach was applied to select those models that best fit each individual
mitochondrial (mt) protein at different taxonomic levels of metazoans. The existing …

Bioinformatics and biophysical studies of intrinsically disordered proteins and regions (IDRs)
note the high entropy at individual sequence positions and in conformations sampled in …

Background Several entropy-based methods have been developed for scoring sequence
conservation in protein multiple sequence alignments. High scoring amino acid positions …

Non-independent evolution of amino acid sites has become a noticeable limitation of most
methods aimed at identifying selective constraints at functionally important amino acid sites …

Candida auris is a globally emerging fungal pathogen responsible for causing nosocomial
outbreaks in healthcare associated settings. It is known to cause infection in all age groups …