Praziquantel for schistosomiasis: single-drug metabolism revisited, mode of action, and resistance

N Vale, MJ Gouveia, G Rinaldi… - Antimicrobial agents …, 2017 - Am Soc Microbiol
Schistosomiasis, a major neglected tropical disease, affects more than 250 million people
worldwide. Treatment of schistosomiasis has relied on the anthelmintic drug praziquantel …

Schistosomiasis control: praziquantel forever?

D Cioli, L Pica-Mattoccia, A Basso, A Guidi - Molecular and biochemical …, 2014 - Elsevier
Since no vaccine exists against schistosomiasis and the molluscs acting as intermediate
hosts are not easy to attack, chemotherapy is the main approach for schistosomiasis control …

Endogenous bioelectric signaling networks: exploiting voltage gradients for control of growth and form

M Levin, G Pezzulo… - Annual review of …, 2017 - annualreviews.org
Living systems exhibit remarkable abilities to self-assemble, regenerate, and remodel
complex shapes. How cellular networks construct and repair specific anatomical outcomes …

Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo

M Levin - Molecular biology of the cell, 2014 - Am Soc Cell Biol
In addition to biochemical gradients and transcriptional networks, cell behavior is regulated
by endogenous bioelectrical cues originating in the activity of ion channels and pumps …

The role of early bioelectric signals in the regeneration of planarian anterior/posterior polarity

F Durant, J Bischof, C Fields, J Morokuma, J LaPalme… - Biophysical …, 2019 - cell.com
Axial patterning during planarian regeneration relies on a transcriptional circuit that confers
distinct positional information on the two ends of an amputated fragment. The earliest known …

The journey to discovering a flatworm target of praziquantel: a long TRP

SK Park, JS Marchant - Trends in parasitology, 2020 - cell.com
Infections caused by parasitic flatworms impose a considerable worldwide health burden.
One of the most impactful is schistosomiasis, a disease caused by parasitic blood flukes …

Planarian regeneration as a model of anatomical homeostasis: recent progress in biophysical and computational approaches

M Levin, AM Pietak, J Bischof - Seminars in cell & developmental biology, 2019 - Elsevier
Planarian behavior, physiology, and pattern control offer profound lessons for regenerative
medicine, evolutionary biology, morphogenetic engineering, robotics, and unconventional …

What is the mechanism of action of praziquantel and how might resistance strike?

PM Cupit, C Cunningham - Future medicinal chemistry, 2015 - Taylor & Francis
Background While S. mansoni and S. japonicum are associated with intestinal
schistosomiasis where mature schistosomes relocate to the mesenteric veins from the liver …

Activity Profile of an FDA-Approved Compound Library against Schistosoma mansoni

G Panic, M Vargas, I Scandale… - PLoS neglected tropical …, 2015 - journals.plos.org
Background As plans to expand mass drug treatment campaigns to fight schistosomiasis
form, worries about reliance on praziquantel as the sole available treatment motivate the …

A review of the genetic determinants of praziquantel resistance in Schistosoma mansoni: Is praziquantel and intestinal schistosomiasis a perfect match?

S Summers, T Bhattacharyya, F Allan… - Frontiers in Tropical …, 2022 - frontiersin.org
Schistosomiasis is a neglected tropical disease (NTD) caused by parasitic trematodes
belonging to the Schistosoma genus. The mainstay of schistosomiasis control is the delivery …