Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful
albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability …

Olignucleotide-based drugs show promise as a novel form of chemotherapy. Among the
hurdles that have to be overcome on the way of applicable nucleic acid therapeutics …

Oligonucleotides constitute a class of potential therapeutic agents that can be used to target
mRNA (antisense strategy), double-stranded DNA (triple-helix strategy), and even proteins …

Ever since the observation that synthetic oligonucleotides and their modified analogues can
be used successfully to modulate the functions of specific genes, 1, 2 the research on …

Antisense oligonucleotides (As-ODNs) are single stranded, synthetically prepared strands of
deoxynucleotide sequences, usually 18–21 nucleotides in length, complementary to the …

We have designed a heterofunctionalized nanoparticle conjugate consisting of a 13-nm gold
nanoparticle (Au NP) containing both antisense oligonucleotides and synthetic peptides …

2 '-Deoxyoligonucleotides and 2 '-O-methyloligoribonucleotides carrying one or more 2 '-
aldehyde groups were synthesized and coupled to peptides containing an N-terminal …

The vasculature of a tumour provides the most effective route by which neoplastic cells may
be reached and eradicated by drugs. The fact that a tumour's vasculature is relatively more …

The use of synthetic oligonucleotides and their mimics to inhibit gene expression by
hybridizing with their target sequences has been hindered by their poor cellular uptake and …

Oligonucleotides are promising tools for in vitro studies where specific downregulation of
proteins is required. In addition, antisense oligonucleotides have been studied in vivo and …