The hnRNPs (heterogeneous nuclear ribonucleoproteins) are RNA-binding proteins with
important roles in multiple aspects of nucleic acid metabolism, including the packaging of …

Many cellular functions require the synthesis of a specific protein or functional cohort of
proteins at a specific time and place in the cell. Local protein synthesis in neuronal dendrites …

Tumor mutational burden and heterogeneity has been suggested to fuel resistance to many
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …

Despite clear evidence that exosomal microRNAs (miRNAs) are able to modulate the
cellular microenvironment and that exosomal RNA cargo selection is deregulated in …

Rare copy-number variation (CNV) is an important source of risk for autism spectrum
disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of …

Tristetraprolin (TTP) is an RNA-binding protein that controls the inflammatory response by
limiting the expression of several proinflammatory cytokines. TTP post-transcriptionally …

Abstract Inositol 1, 4, 5‐trisphosphate (IP3) is a second messenger that induces the release
of Ca2+ from the endoplasmic reticulum (ER). The IP3 receptor (IP3R) was discovered as a …

Mislocalization and abnormal deposition of TDP-43 into the cytoplasm (TDP-43
proteinopathy) is a hallmark in neurons of amyotrophic lateral sclerosis (ALS) and …

Purpose To maximize the discovery of potentially pathogenic variants to better understand
the diagnostic utility of genome sequencing (GS) and to assess how the presence of multiple …

In brain, mRNAs are transported from the cell body to the processes, allowing for local
protein translation at sites distant from the nucleus. Using subcellular fractionation, we …