Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV
infection contributes to haematological abnormalities observed in HIV patients. The bone …

The interaction between human immunodeficiency virus (HIV) and hematopoietic
stem/progenitor cells (HSPCs) has been of great interest. However, it remains unclear …

Latent reservoirs in human-immunodeficiency-virus-1 (HIV-1)-infected individuals represent
a major obstacle in finding a cure for HIV-1. Hematopoietic stem and progenitor cells …

Therapeutic gene delivery to hematopoietic stem cells (HSCs) holds great potential as a life-
saving treatment of monogenic, oncologic, and infectious diseases. However, clinical gene …

Highlights•Two main groups of LVs-inhibiting molecules are described.•PPRs recognize LV-
derived nucleic acids and activate the host immune response.•Other RFs block reverse …

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Although gene transfer to hematopoietic stem cells (HSCs) has shown therapeutic efficacy in
recent trials for several individuals with inherited disorders, transduction incompleteness of …

HIV-1 causes the loss of CD4+ T cells via depletion or impairment of their production. The
latter involves infection of thymocytes, but the involvement of hematopoietic CD34+ cells …

Individuals who have been preinfected by human cytomegalovirus (HCMV) are more prone
to AIDS disease progression after subsequent HIV-1 infection but the underlying mechanism …

Background Retroviral vectors are derived from wild-type retroviruses, can be used to study
retrovirus-host interactions and are effective tools in gene and cell therapy. However …