Regulation of wound healing by the NRF2 transcription factor—More than cytoprotection

P Hiebert, S Werner - International journal of molecular sciences, 2019 - mdpi.com
The nuclear factor-erythroid 2-related factor 2 (NRF2) transcription factor plays a central role
in mediating the cellular stress response. Due to their antioxidant properties, compounds …

[HTML][HTML] The Nrf2 transcription factor: a multifaceted regulator of the extracellular matrix

P Hiebert - Matrix Biology Plus, 2021 - Elsevier
The transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) is widely recognized
as a master regulator of the cellular stress response by facilitating the transcription of …

Lycopene prevents DEHP-induced hepatic oxidative stress damage by crosstalk between AHR–Nrf2 pathway

Y Zhao, RK Bao, SY Zhu, M Talukder, JG Cui… - Environmental …, 2021 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a widespread plasticizer that persists in the
environment and can significantly contribute to serious health hazards of liver especially …

Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease

HH Kim, YR Shim, SE Choi, MH Kim, G Lee… - … & Molecular Medicine, 2023 - nature.com
Chronic alcohol consumption often induces hepatic steatosis but rarely causes severe
inflammation in Kupffer cells (KCs) despite the increased hepatic influx of …

Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver

GN Cholico, K Orlowska, RR Fling, WJ Sink… - Scientific Reports, 2023 - nature.com
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental
contaminant that induces the progression of steatosis to steatohepatitis with fibrosis in mice …

2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice

KA Fader, R Nault, CM Doskey, RR Fling… - Scientific reports, 2019 - nature.com
Aryl hydrocarbon receptor (AhR) activation is reported to alter the hepatic expression of
circadian clock regulators, however the impact on clock-controlled metabolism has not been …

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice

RR Fling, CM Doskey, KA Fader, R Nault… - Scientific Reports, 2020 - nature.com
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD), a persistent environmental
contaminant, induces steatosis that can progress to steatohepatitis with fibrosis, pathologies …

Dioxin-elicited decrease in cobalamin redirects propionyl-CoA metabolism to the β–oxidation-like pathway resulting in acrylyl-CoA conjugate buildup

K Orlowska, RR Fling, R Nault, WJ Sink… - Journal of Biological …, 2022 - ASBMB
2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant that
induces diverse biological and toxic effects, including reprogramming intermediate …

Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation

GN Cholico, RR Fling, NA Zacharewski, KA Fader… - Scientific reports, 2021 - nature.com
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD), a persistent environmental
contaminant, induces steatosis by increasing hepatic uptake of dietary and mobilized …

Cystine/Glutamate Xc Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure …

K Orlowska, RR Fling, R Nault… - Chemical Research …, 2023 - ACS Publications
Exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) has been associated with the
induction of oxidative stress and the progression of steatosis to steatohepatitis with fibrosis. It …