The modification of eukaryotic proteins by isoprenoid lipids, which is known as prenylation,
controls the localization and activity of a range of proteins that have crucial functions in …

RAS and many other oncogenic proteins undergo a complex series of post-translational
modifications that are initiated by the addition of an isoprenoid lipid through a process …

Rho GTPases (20 human members) comprise a major branch of the Ras superfamily of
small GTPases, and aberrant Rho GTPase function has been implicated in oncogenesis and …

Background. Macrolides have received considerable attention for their anti‐inflammatory
and immunomodulatory actions beyond the antibacterial effect. These two properties may …

Many key regulatory proteins, including members of the Ras family of GTPases, are modified
at their C terminus by a process termed prenylation. This processing is initiated by the …

Posttranslational modifications increase the complexity and functional diversity of proteins in
response to complex external stimuli and internal changes. Among these, protein lipidations …

The Ras and Rho GTPases contribute to the initiation and progression of cancer by
subverting the normal regulation of specific intracellular signalling pathways. As a result …

Focal adhesion kinase (FAK) is a key component of cell-substratum adhesions, known as
focal adhesion complexes. Growing evidence indicates that FAK is important in …

Cigarette smoke (CS) exposure increases the risk for acute respiratory distress syndrome in
humans and promotes alveolar–capillary barrier permeability and acute lung injury in …

Epidemiologic evidence indicates that cigarette smoke (CS) is associated with the
development of acute lung injury (ALI). We have previously shown that brief CS exposure …