Cancer stem cells—origins and biomarkers: perspectives for targeted personalized therapies

L Walcher, AK Kistenmacher, H Suo, R Kitte… - Frontiers in …, 2020 - frontiersin.org
The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …

BDNF and its signaling in cancer

M Malekan, SS Nezamabadi, E Samami… - Journal of cancer …, 2023 - Springer
Purpose Brain-derived neurotrophic factor (BDNF) belongs to the family of neurotrophic
factors that can potentially increase cancer cell growth, survival, proliferation, anoikis, and …

Isolation and characterization of head and neck cancer-derived peritumoral and cancer-associated fibroblasts

J Zhou, S Schwenk-Zieger, G Kranz, C Walz… - Frontiers in …, 2022 - frontiersin.org
Introduction Head and neck squamous cell carcinomas (HNSCC) are characterized by
strong cellular and molecular heterogeneity and treatment resistance entailing poor survival …

Edaravone alleviated propofol‐induced neural injury in developing rats by BDNF/TrkB pathway

Y Yang, J Yi, M Pan, B Hu… - Journal of Cellular and …, 2021 - Wiley Online Library
As a variety of free radical scavenger, edaravone has shown its potential in producing
antioxidant, anti‐inflammatory and neuroprotective effects in various disease models …

Tetrahydropalmatine regulates BDNF through TrkB/CAM interaction to alleviate the neurotoxicity induced by methamphetamine

L Liu, M Liu, W Zhao, YL Zhao… - ACS Chemical …, 2021 - ACS Publications
Tetrahydropalmatine (THP) has analgesic, hypnotic, sedative, and other pharmacological
effects. Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal …

Astragaloside IV ameliorates radiation‐induced nerve cell damage by activating the BDNF/TrkB signaling pathway

X Liu, Y Ding, C Jiang, X Ma, Y Xin, Y Li… - Phytotherapy …, 2023 - Wiley Online Library
Radiation can induce nerve cell damage. Synapse connectivity and functionality are thought
to be the essential foundation of all cognitive functions. Therefore, treating and preventing …

Identification of potential inhibitors of tropomyosin receptor kinase B targeting CNS-related disorders and cancers

MA Hakami, BS Alotaibi, A Hazazi… - Journal of …, 2024 - Taylor & Francis
Tropomyosin receptor kinase B (TrkB), also known as neurotrophic tyrosine kinase receptor
type 2 (NTRK2), is a protein that belongs to the family of receptor tyrosine kinases (RTKs) …

BDNF Acts as a Prognostic Factor Associated with Tumor‐Infiltrating Th2 Cells in Pancreatic Adenocarcinoma

Y Zhu, C Zhang, D Zhao, W Li, Z Zhao, S Yao… - Disease …, 2021 - Wiley Online Library
Pancreatic adenocarcinoma (PAAD) is an extremely lethal disease worldwide. Brain‐
derived neurotrophic factor (BDNF) is a critical member of the neurotrophin polypeptide …

[HTML][HTML] NTRK gene expression analysis in oral squamous cell carcinoma Mexican population

LS Escoto-Vasquez, J Portilla-Robertson… - Dentistry Journal, 2024 - mdpi.com
Oral cancer holds the sixth position in malignancies worldwide; 90% correspond to oral
squamous cell carcinoma (OSCC). Diverse reports suggest that NTRK genes and their …

Sevoflurane leads to learning and memory dysfunction via breaking the balance of tPA/PAI-1

Y Dong, W Hong, Z Tang, Y Gao, X Wu, H Liu - Neurochemistry …, 2020 - Elsevier
Exposure to general anesthesia in early childhood may lead to adverse effects on
adolescent neurocognition. This study investigated the effects of multiple inhalations of …