Osteosarcoma

HC Beird, SS Bielack, AM Flanagan, J Gill… - Nature reviews Disease …, 2022 - nature.com
Osteosarcoma is the most common primary malignant tumour of the bone. Osteosarcoma
incidence is bimodal, peaking at 18 and 60 years of age, and is slightly more common in …

Second near-infrared photothermal materials for combinational nanotheranostics

C Xu, K Pu - Chemical Society Reviews, 2021 - pubs.rsc.org
Second near-infrared photothermal therapy (NIR-II PTT, 1000–1500 nm) has recently
emerged as a new phototherapeutic modality with the advantages of deeper penetration …

Molecular biology of osteosarcoma

AM Czarnecka, K Synoradzki, W Firlej, E Bartnik… - Cancers, 2020 - mdpi.com
Osteosarcoma (OS) is the most frequent primary bone cancer in children and adolescents
and the third most frequent in adults. Many inherited germline mutations are responsible for …

The osteosarcoma microenvironment: a complex but targetable ecosystem

I Corre, F Verrecchia, V Crenn, F Redini, V Trichet - Cells, 2020 - mdpi.com
Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children,
adolescents, and young adults, and with a second peak of incidence in elderly individuals …

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

J Liao, R Han, Y Wu, Z Qian - Bone research, 2021 - nature.com
Bone tumors, especially those in osteosarcoma, usually occur in adolescents. The standard
clinical treatment includes chemotherapy, surgical therapy, and radiation therapy …

Osteosarcoma: a surveillance, epidemiology, and end results program‐based analysis from 1975 to 2017

S Cole, DM Gianferante, B Zhu, L Mirabello - Cancer, 2022 - Wiley Online Library
Background Osteosarcoma is the most common primary bone malignancy. As a rare cancer,
population‐based studies remain small with limited information on finer demographic …

Tumor-associated macrophages in osteosarcoma: from mechanisms to therapy

F Cersosimo, S Lonardi, G Bernardini, B Telfer… - International journal of …, 2020 - mdpi.com
Osteosarcomas (OSs) are bone tumors most commonly found in pediatric and adolescent
patients characterized by high risk of metastatic progression and recurrence after therapy …

Future directions in the treatment of osteosarcoma

A Smrke, PM Anderson, A Gulia, S Gennatas… - Cells, 2021 - mdpi.com
Osteosarcoma is the most common primary bone sarcoma and is often diagnosed in the 2nd–
3rd decades of life. Response to the aggressive and highly toxic neoadjuvant methotrexate …

[HTML][HTML] Gold nanorods and nanohydroxyapatite hybrid hydrogel for preventing bone tumor recurrence via postoperative photothermal therapy and bone regeneration …

J Liao, K Shi, Y Jia, Y Wu, Z Qian - Bioactive materials, 2021 - Elsevier
Osteosarcoma is a malignant bone tumor, which often occurs in adolescents. However,
surgical resection usually fails to completely remove the tumor clinically, which has been the …

[HTML][HTML] TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling

W Liu, Y Zhao, G Wang, S Feng, X Ge, W Ye, Z Wang… - Redox Biology, 2022 - Elsevier
Osteosarcoma (OS) is a malignant bone tumor that mainly occurs in adolescents. It is
accompanied by a high rate of lung metastasis, and high mortality. Recent studies have …