Cohesin mediates chromatin loop formation across the genome by extruding chromatin
between convergently oriented CTCF-binding elements. Recent studies indicate that …

The initiation of V (D) J recombination by the recombination activating gene 1 (RAG1) and
RAG2 proteins is carefully orchestrated to ensure that antigen receptor gene assembly …

The transcription factor Pax5 is essential for commitment of lymphoid progenitors to the B
lymphocyte lineage. Pax5 fulfils a dual role by repressing B lineage'inappropriate'genes and …

Abstract V (D) J recombination assembles antigen receptor variable region genes from
component germline variable (V), diversity (D), and joining (J) gene segments. For B cells …

The generation of B-lymphocytes from hematopoietic stem cells is controlled by multiple
transcription factors regulating distinct developmental aspects. Ikaros and PU. 1 act in …

Abstract V (D) J recombination assembles antigen receptor genes from component gene
segments. We review findings that have shaped our current understanding of this …

Immunoglobulin heavy chain (IgH) variable region exons are assembled from VH, D and JH
gene segments in developing B lymphocytes. Within the 2.7-megabase mouse Igh locus, V …

The subnuclear location and chromatin state of the immunoglobulin heavy-chain (IgH) locus
have been implicated in the control of V (D) J recombination. VH-to-DJH rearrangement of …

The contribution of proliferation to B lymphocyte homeostasis and antigen responses is
largely unknown. We quantified the replication history of mouse and human B lymphocyte …

The B cell lineage of the hematopoietic system is responsible for the generation of high-
affinity antibodies, which provide humoral immunity for protection against foreign pathogens …