An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

Many ion channels have been described as mechanosensitive according to various criteria.
Most broadly defined, an ion channel is called mechanosensitive if its activity is controlled by …

Iron overload causes progressive organ damage and is associated with arthritis, liver
damage, and heart failure. Elevated iron levels are present in 1%–5% of individuals; …

Most cancer cells are exposed to altered extracellular environments, such as an increase in
extracellular matrix (ECM) stiffness and soluble signals consisting of growth factors and …

Piezo-type mechanosensitive ion channel component 1 (Piezo1) is a mechanosensitive ion
channel protein that is evolutionarily conserved and multifunctional. It plays an important …

Neural stem cells (NSCs) are used to treat various nervous system diseases because of
their self‐renewal ability and multidirectional differentiation potential. However, an …

Since the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a
significant amount of research conducted to explore its regulatory role in the physiology and …

Background Cervical cancer, which is a significant public health concern in women,
currently lacks effective therapeutic drugs. Matrine, a constituent of the traditional Chinese …

Due to its pivotal role in orchestrating vital cellular functions and metabolic processes, iron is
an essential component of the human body and a main micronutrient in the human diet …

Pulmonary endothelial cell dysfunction plays an important role in ionizing radiation (IR)-
induced lung injury. Whether pulmonary endothelial cell ferroptosis occurs after IR and what …