Since the identification of the hepatitis C virus (HCV) 20 years ago, much progress has been
made in our understanding of its life cycle and interaction with the host immune system …

Hepatitis viruses are major threats to human health. During the last decade, highly diverse
viruses related to human hepatitis viruses were found in animals other than primates …

The development of resistance to direct-acting antivirals (DAAs) targeting the hepatitis C
virus (HCV) can compromise therapy. However, mechanisms that determine prevalence and …

ABSTRACT Hypervariable region 1 (HVR1) of hepatitis C virus (HCV) E2 envelope
glycoprotein has been implicated in virus neutralization and persistence. We deleted HVR1 …

Hepatitis C virus (HCV) remains a public health problem of global importance, even in the
era of potent directly-acting antiviral drugs. In this chapter, I discuss immune responses to …

Hepatitis C virus (HCV) is a hepatotropic RNA virus with an extraordinary propensity to
persist in the vast majority of infected individuals. During replication, because of the inherent …

Chronic infections with hepatitis B virus (HBV) and/or hepatitis C virus (HCV) are the major
causes of cirrhosis globally. It takes 10-20 years to progress from viral hepatitis to cirrhosis …

ABSTRACT CD8+-T-cell responses play an important role in the containment and clearance
of hepatitis C virus (HCV) infection, and an association between viral persistence and …

In this review, we summarize the relevant scientific advances that led to the development of
infectious cell culture systems for hepatitis C virus (HCV) with the corresponding challenges …

Hepatitis C virus (HCV)-specific T cells are key factors in the outcome of acute HCV infection
and in protective immunity. This review recapitulates the steps that immunologists have …