Large-scale functional connectivity networks in the rodent brain

A Gozzi, AJ Schwarz - Neuroimage, 2016 - Elsevier
Abstract Resting-state functional Magnetic Resonance Imaging (rsfMRI) of the human brain
has revealed multiple large-scale neural networks within a hierarchical and complex …

Purinergic system in psychiatric diseases

A Cheffer, ARG Castillo, J Corrêa-Velloso… - Molecular …, 2018 - nature.com
Psychiatric disorders are debilitating diseases, affecting> 80 million people worldwide.
There are no causal cures for psychiatric disorders and available therapies only treat the …

Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes

V Zerbi, M Pagani, M Markicevic, M Matteoli… - Molecular …, 2021 - nature.com
Abstract Autism Spectrum Disorder (ASD) is characterized by substantial, yet highly
heterogeneous abnormalities in functional brain connectivity. However, the origin and …

Deficits in mesolimbic reward pathway underlie social interaction impairments in children with autism

K Supekar, J Kochalka, M Schaer, H Wakeman, S Qin… - Brain, 2018 - academic.oup.com
Lack of interest in social interaction is a hallmark of autism spectrum disorder. Animal
studies have implicated the mesolimbic reward pathway in driving and reinforcing social …

SHANK3 controls maturation of social reward circuits in the VTA

S Bariselli, S Tzanoulinou, C Glangetas… - Nature …, 2016 - nature.com
Haploinsufficiency of SHANK3, encoding the synapse scaffolding protein SHANK3, leads to
a highly penetrant form of autism spectrum disorder. How SHANK3 insufficiency affects …

The BTBR mouse model of idiopathic autism–current view on mechanisms

KZ Meyza, DC Blanchard - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Autism spectrum disorder (ASD) is the most commonly diagnosed neurodevelopmental
disorder, with current estimates of more than 1% of affected children across nations. The …

Neural mechanisms underlying repetitive behaviors in rodent models of autism spectrum disorders

T Gandhi, CC Lee - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Autism spectrum disorder (ASD) is comprised of several conditions characterized by
alterations in social interaction, communication, and repetitive behaviors. Genetic and …

Animal functional magnetic resonance imaging: trends and path toward standardization

F Mandino, DH Cerri, CM Garin, M Straathof… - Frontiers in …, 2020 - frontiersin.org
Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive
window into brain activity. A collection of associated methods aims to replicate observations …

The power of using functional fMRI on small rodents to study brain pharmacology and disease

E Jonckers, D Shah, J Hamaide, M Verhoye… - Frontiers in …, 2015 - frontiersin.org
Functional magnetic resonance imaging (fMRI) is an excellent tool to study the effect of
pharmacological modulations on brain function in a non-invasive and longitudinal manner …

P-cresol alters brain dopamine metabolism and exacerbates autism-like behaviors in the BTBR mouse

T Pascucci, M Colamartino, E Fiori, R Sacco, A Coviello… - Brain sciences, 2020 - mdpi.com
Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder
characterized by deficits in social interaction/communication, stereotypic behaviors …