Reactive gliosis in Alzheimer's disease: a crucial role for cognitive impairment and memory loss

RAL De Sousa - Metabolic Brain Disease, 2022 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder that leads to cognitive decline
and memory loss. Insulin resistance in central nervous system (CNS) is a common feature in …

Molecular mechanisms involved in the protective actions of Selective Estrogen Receptor Modulators in brain cells

E Baez-Jurado, MA Rincón-Benavides… - Frontiers in …, 2019 - Elsevier
Synthetic selective modulators of the estrogen receptors (SERMs) have shown to protect
neurons and glial cells against toxic insults. Among the most relevant beneficial effects …

Differential effects of astrocyte manipulations on learned motor behavior and neuronal ensembles in the motor cortex

C Delepine, J Shih, K Li, P Gaudeaux… - Journal of …, 2023 - Soc Neuroscience
Although motor cortex is crucial for learning precise and reliable movements, whether and
how astrocytes contribute to its plasticity and function during motor learning is unknown …

Mecp2 knock-out astrocytes affect synaptogenesis by interleukin 6 dependent mechanisms

E Albizzati, M Breccia, E Florio, C Cabasino… - Iscience, 2024 - cell.com
Synaptic abnormalities are a hallmark of several neurological diseases, and clarification of
the underlying mechanisms represents a crucial step toward the development of therapeutic …

Preeclamptic placentae release factors that damage neurons: implications for foetal programming of disease

H Scott, TJ Phillips, GC Stuart, MF Rogers… - Neuronal …, 2018 - portlandpress.com
Prenatal development is a critical period for programming of neurological disease.
Preeclampsia, a pregnancy complication involving oxidative stress in the placenta, has been …

Progress of Astrocyte-Neuron Crosstalk in Central Nervous System Diseases

Y Zhang, Z Wang, F Xu, Z Liu, Y Zhao, LZ Yang… - Neurochemical …, 2024 - Springer
Neurons are the primary cells responsible for information processing in the central nervous
system (CNS). However, they are vulnerable to damage and insult in a variety of …

Excitotoxic Storms of Ischemic Stroke: A Non-neuronal Perspective

X Yang, H Yu, J Li, N Li, C Li, D Xu, H Zhang… - Molecular …, 2024 - Springer
Numerous neurological disorders share a fatal pathologic process known as glutamate
excitotoxicity. Among which, ischemic stroke is the major cause of mortality and disability …

Integrative neurovascular coupling and neurotransmitter analyses in anisometropic and visual deprivation amblyopia children

X Zhang, L Liu, Y Li, X Li, K Wang, S Han, M Wang… - iScience, 2024 - cell.com
The association between visual abnormalities and impairments in cerebral blood flow and
brain region potentially results in neural dysfunction of amblyopia. Nevertheless, the …

Longitudinal FRET imaging of glucose and lactate dynamics and response to therapy in breast cancer cells

J Yang, T Davis, AS Kazerouni, YI Chen… - Molecular imaging and …, 2021 - Springer
Purpose The reprogramming of cellular metabolism is a hallmark of cancer. The ability to
noninvasively assay glucose and lactate concentrations in cancer cells would improve our …

Studying Synaptic Integration of Glioma Cells into Neural Circuits

K Shamardani, KR Taylor, T Barron… - New Technologies for …, 2024 - Springer
Nervous system activity regulates homeostasis, development, and plasticity of the brain.
Certain glial cell populations regulate neuronal activity by controlling neurotransmitter …