Despite the success of targeted therapies in cancer treatment, therapy-induced resistance
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …

The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …

Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

Cancer stem cells (CSCs) are a distinct population of cells within tumors with capabilities of
self-renewal and tumorigenicity. CSCs play a pivotal role in cancer progression, metastasis …

Simple Summary Cancer is one of the most debated problems all over the world. Cancer
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …

Intratumoral heterogeneity is a major ongoing challenge in the effective therapeutic targeting
of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed …

Simple Summary The cancer cells in solid tumors are embedded in a complex connective
tissue matrix composed of various other cell types, ie, mesenchymal stroma/stem-like cells …

The physiological state of the tumor microenvironment (TME) plays a central role in cancer
development due to multiple universal features that transcend heterogeneity and niche …

Liver tumor-initiating cells (TICs) are involved in liver tumorigenesis, metastasis, drug
resistance, and relapse, but the regulatory mechanisms of liver TICs are largely unknown …

In embryonic development and throughout life, there are some cells can exhibit phenotypic
plasticity. Phenotypic plasticity is the ability of cells to differentiate into multiple lineages. In …