Life and death of circulating cell-free DNA

A Kustanovich, R Schwartz, T Peretz… - Cancer biology & …, 2019 - Taylor & Francis
Tumor-specific, circulating cell-free DNA in liquid biopsies is a promising source of
biomarkers for minimally invasive serial monitoring of treatment responses in cancer …

Bridging biological cfDNA features and machine learning approaches

T Moser, S Kühberger, I Lazzeri, G Vlachos, E Heitzer - Trends in Genetics, 2023 - cell.com
Liquid biopsies (LBs), particularly using circulating tumor DNA (ctDNA), are expected to
revolutionize precision oncology and blood-based cancer screening. Recent technological …

Early stage NSCLC—challenges to implementing ctDNA-based screening and MRD detection

C Abbosh, NJ Birkbak, C Swanton - Nature Reviews Clinical Oncology, 2018 - nature.com
Circulating tumour DNA (ctDNA) refers to the fraction of cell-free DNA in a patient's blood
that originates from a tumour. Advances in DNA sequencing technologies and our …

High‐performance nucleic acid sensors for liquid biopsy applications

J Das, SO Kelley - Angewandte Chemie International Edition, 2020 - Wiley Online Library
Circulating tumour nucleic acids (ctNAs) are released from tumours cells and can be
detected in blood samples, providing a way to track tumors without requiring a tissue …

Machine learning-based radiomics strategy for prediction of cell proliferation in non-small cell lung cancer

Q Gu, Z Feng, Q Liang, M Li, J Deng, M Ma… - European journal of …, 2019 - Elsevier
Purpose To explore the feasibility and performance of machine learning-based radiomics
classifier to predict the cell proliferation (Ki-67) in non-small cell lung cancer (NSCLC) …

Liquid biopsies in lung cancer

M Kemper, C Krekeler, K Menck, G Lenz, G Evers… - Cancers, 2023 - mdpi.com
Simple Summary Liquid biopsy has recently been introduced as a novel method in cancer
diagnostics. It is less invasive for patients than conventional tissue biopsies, as the assay …

Correlation between circulating tumour DNA and metabolic tumour burden in metastatic melanoma patients

AC McEvoy, L Warburton, Z Al-Ogaili, L Celliers… - BMC cancer, 2018 - Springer
Abstract Background Circulating tumour DNA (ctDNA) may serve as a measure of tumour
burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not …

The current status of cell‐free human papillomavirus DNA as a biomarker in cervical cancer and other HPV‐associated tumors: A review

L Sivars, K Palsdottir… - … Journal of Cancer, 2023 - Wiley Online Library
Tumor cells release fragments of their DNA into the circulation, so called cell‐free tumor
DNA (ctDNA), allowing for analysis of tumor DNA in a simple blood test, that is, liquid biopsy …

[HTML][HTML] Measuring KRAS mutations in circulating tumor DNA by droplet digital PCR and next-generation sequencing

C Demuth, KLG Spindler, JS Johansen… - Translational …, 2018 - Elsevier
Measuring total cell-free DNA (cfDNA) or cancer-specific mutations herein has presented as
new tools in aiding the treatment of cancer patients. Studies show that total cfDNA bears …

[HTML][HTML] Circulating tumor DNA allele fraction: a candidate biological signal for multicancer early detection tests to assess the clinical significance of cancers

J Bredno, O Venn, X Chen, P Freese… - The American Journal of …, 2022 - Elsevier
Current imaging-based cancer screening approaches provide useful but limited prognostic
information. Complementary to existing screening tests, cell-free DNA–based multicancer …