Immunity to Cryptosporidium: insights into principles of enteric responses to infection

RD Pardy, BA Wallbank, B Striepen… - Nature Reviews …, 2024 - nature.com
Cryptosporidium parasites replicate within intestinal epithelial cells and are an important
cause of diarrhoeal disease in young children and in patients with primary and acquired …

Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus

V Greigert, I Saraav, J Son, Y Zhu, D Dayao, A Antia… - Gut …, 2024 - Taylor & Francis
Cryptosporidiosis is a major cause of severe diarrheal disease in infants from resource poor
settings. The majority of infections are caused by the human-specific pathogen C. hominis …

Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis

AP Wright, TJ Nice - Current opinion in immunology, 2024 - Elsevier
Interferon (IFN) was discovered based on interference with virus production, and three types
of IFN are now defined. Since its discovery, IFN's roles have expanded beyond viruses to …

Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN-γ on parasite restriction

RD Pardy, KA Walzer, BA Wallbank, JH Byerly… - Plos …, 2024 - journals.plos.org
The production of IFN-γ is crucial for control of multiple enteric infections, but its impact on
intestinal epithelial cells (IEC) is not well understood. Cryptosporidium parasites exclusively …

Cryptosporidium parvum hijacks a host's long noncoding RNA U90926 to evade intestinal epithelial cell-autonomous antiparasitic defense

ML Graham, M Li, AY Gong, S Deng, K Jin… - Frontiers in …, 2023 - frontiersin.org
Cryptosporidium is a zoonotic apicomplexan parasite that infects the gastrointestinal
epithelium and other mucosal surfaces in humans. It is an important opportunistic pathogen …

Screening and Optimization of α‐Glucosidase Inhibitor Production by Potent Strain of Bacillus subtilis Isolated from Peruyaan, Fermented Soy‐Food of Northeast …

ME Kabir, A Borah, H Barman… - Journal of Food …, 2024 - Wiley Online Library
Background. Fermented soy foods exhibit the capability to inhibit the α‐glucosidase enzyme.
The bacteria isolated from these fermented soy foods may contribute to the production of a …

LncRNA Nostrill promotes interferon-γ-stimulated gene transcription and facilitates intestinal epithelial cell-intrinsic anti-Cryptosporidium defense

Z Sharmin, K Jin, AY Gong, S Deng, C Pok… - Frontiers in …, 2024 - frontiersin.org
Intestinal epithelial cells possess the requisite molecular machinery to initiate cell-intrinsic
defensive responses against intracellular pathogens, including intracellular parasites …

A virus associated with the zoonotic pathogen Plasmodium knowlesi causing human malaria is a member of a diverse and unclassified viral taxon

ME Petrone, J Charon, MJ Grigg, T William… - Virus …, 2024 - academic.oup.com
The Apicomplexa are a phylum of single-celled eukaryotes that can infect humans and
include the mosquito-borne parasite Plasmodium, the cause of malaria. Viruses that infect …

The First Identification of Cryptosporidium parvum Virus-1 (CSpV1) in Hanwoo (Bos taurus coreanae) Calves in Korea

JB Chae, SU Shin, S Kim, YM Jo, H Roh, H Chae… - Veterinary …, 2023 - mdpi.com
Simple Summary Cryptosporidium is a parasite that causes digestive diseases in cows, and
a virus called Cryptosporidium parvum virus-1 (CSpV1) is associated with it. We investigated …

A parasite odyssey: An RNA virus concealed in Toxoplasma gondii

P Gupta, A Hiller, J Chowdhury, D Lim, DY Lim… - Virus …, 2024 - academic.oup.com
We are entering a 'Platinum Age of Virus Discovery', an era marked by exponential growth in
the discovery of virus biodiversity, and driven by advances in metagenomics and …