[HTML][HTML] Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy

Y Xu, J Xiong, X Sun, H Gao - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Cancer immunotherapy has significantly flourished and revolutionized the limited
conventional tumor therapies, on account of its good safety and long-term memory ability …

Multifunctional nanoparticle-mediated combining therapy for human diseases

X Li, X Peng, M Zoulikha, GF Boafo, KT Magar… - … and Targeted Therapy, 2024 - nature.com
Combining existing drug therapy is essential in developing new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …

Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities

Y Liu, X Zhou, X Wang - Journal of Hematology & Oncology, 2021 - Springer
B-cell lymphoma is a group of hematological malignancies with high clinical and biological
heterogeneity. The pathogenesis of B-cell lymphoma involves a complex interaction …

Barriers to chimeric antigen receptor T-cell (CAR-T) therapies in clinical practice

A Gajra, A Zalenski, A Sannareddy… - Pharmaceutical …, 2022 - Springer
Chimeric antigen receptor T-cell (CAR-T) therapy is a revolutionary cancer treatment
modality where a patient's own T cells are collected and engineered ex vivo to express a …

From CD16a biology to antibody-dependent cell-mediated cytotoxicity improvement

L Coënon, M Villalba - Frontiers in Immunology, 2022 - frontiersin.org
Antibody-dependent cell-mediated cytotoxicity (ADCC) is a potent cytotoxic mechanism that
is mainly mediated in humans by natural killer (NK) cells. ADCC mediates the clinical benefit …

ROR1-targeting switchable CAR-T cells for cancer therapy

H Peng, T Nerreter, K Mestermann, J Wachter, J Chang… - Oncogene, 2022 - nature.com
The success of chimeric antigen receptor T cell (CAR-T) therapy in the treatment of
hematologic malignancies has prompted the development of numerous CAR-T …

CAR-macrophage: Breaking new ground in cellular immunotherapy

T Huang, C Bei, Z Hu, Y Li - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
Chimeric Antigen Receptor (CAR) technology has revolutionized cellular immunotherapy,
particularly with the success of CAR-T cells in treating hematologic malignancies. However …

Recent findings on chimeric antigen receptor (CAR)-engineered immune cell therapy in solid tumors and hematological malignancies

A Keshavarz, A Salehi, S Khosravi, Y Shariati… - Stem Cell Research & …, 2022 - Springer
Advancements in adoptive cell therapy over the last four decades have revealed various
new therapeutic strategies, such as chimeric antigen receptors (CARs), which are dedicated …

Three Strategies in Engineering Nanomedicines for Tumor Microenvironment‐Enabled Phototherapy

S He, X Jia, S Feng, J Hu - Small, 2023 - Wiley Online Library
Canonical phototherapeutics have several limitations, including a lack of tumor selectivity,
nondiscriminatory phototoxicity, and tumor hypoxia aggravation. The tumor …

Immunotherapy for prostate cancer: a current systematic review and patient centric perspectives

L Rehman, MH Nisar, W Fatima, A Sarfraz… - Journal of clinical …, 2023 - mdpi.com
Prostate cancer is the most commonly diagnosed cancer in men worldwide, making up 21%
of all cancer cases. With 345,000 deaths per year owing to the disease, there is an urgent …