Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity
Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
The biology of ependymomas and emerging novel therapies
Ependymomas are rare central nervous system tumours that can arise in the brain's
supratentorial region or posterior fossa, or in the spinal cord. In 1924, Percival Bailey …
supratentorial region or posterior fossa, or in the spinal cord. In 1924, Percival Bailey …
GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas
Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas
(DMGs) are universally lethal paediatric tumours of the central nervous system. We have …
(DMGs) are universally lethal paediatric tumours of the central nervous system. We have …
Gradient of developmental and injury response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity
Glioblastomas harbor diverse cell populations, including rare glioblastoma stem cells
(GSCs) that drive tumorigenesis. To characterize functional diversity within this population …
(GSCs) that drive tumorigenesis. To characterize functional diversity within this population …
Integrative spatial analysis of cell morphologies and transcriptional states with MUSE
Spatial transcriptomics enables the simultaneous measurement of morphological features
and transcriptional profiles of the same cells or regions in tissues. Here we present multi …
and transcriptional profiles of the same cells or regions in tissues. Here we present multi …
Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance
Rhabdomyosarcoma (RMS) is a group of pediatric cancers with features of developing
skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest …
skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest …
Interfacing Seurat with the R tidy universe
Motivation Seurat is one of the most popular software suites for the analysis of single-cell
RNA sequencing data. Considering the popularity of the tidyverse ecosystem, which offers a …
RNA sequencing data. Considering the popularity of the tidyverse ecosystem, which offers a …
BAF complex maintains glioma stem cells in pediatric H3K27M glioma
Diffuse midline gliomas are uniformly fatal pediatric central nervous system cancers that are
refractory to standard-of-care therapeutic modalities. The primary genetic drivers are a set of …
refractory to standard-of-care therapeutic modalities. The primary genetic drivers are a set of …
Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis
Nuclear localization of HIPPO-YAP fusion proteins has been implicated in supratentorial
ependymoma development. Here, unexpectedly, we find that liquid–liquid phase separation …
ependymoma development. Here, unexpectedly, we find that liquid–liquid phase separation …
ZFTA–RELA dictates oncogenic transcriptional programs to drive aggressive supratentorial ependymoma
A Arabzade, Y Zhao, S Varadharajan, HC Chen… - Cancer discovery, 2021 - AACR
More than 60% of supratentorial ependymomas harbor a ZFTA–RELA (ZRfus) gene fusion
(formerly C11orf95–RELA). To study the biology of ZRfus, we developed an autochthonous …
(formerly C11orf95–RELA). To study the biology of ZRfus, we developed an autochthonous …