Mechanism and applications of CRISPR/Cas-9-mediated genome editing
M Asmamaw, B Zawdie - Biologics: targets and therapy, 2021 - Taylor & Francis
Clustered regularly interspaced short palindromic repeat (CRISPR) and their associated
protein (Cas-9) is the most effective, efficient, and accurate method of genome editing tool in …
protein (Cas-9) is the most effective, efficient, and accurate method of genome editing tool in …
CRISPR/Cas gene therapy
B Zhang - Journal of cellular physiology, 2021 - Wiley Online Library
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated
enzyme (Cas) is a naturally occurring genome editing tool adopted from the prokaryotic …
enzyme (Cas) is a naturally occurring genome editing tool adopted from the prokaryotic …
Programmable inhibition and detection of RNA viruses using Cas13
The CRISPR effector Cas13 could be an effective antiviral for single-stranded RNA (ssRNA)
viruses because it programmably cleaves RNAs complementary to its CRISPR RNA …
viruses because it programmably cleaves RNAs complementary to its CRISPR RNA …
Transcriptional and epigenetic regulators of human CD8+ T cell function identified through orthogonal CRISPR screens
Clinical response to adoptive T cell therapies is associated with the transcriptional and
epigenetic state of the cell product. Thus, discovery of regulators of T cell gene networks and …
epigenetic state of the cell product. Thus, discovery of regulators of T cell gene networks and …
[HTML][HTML] Sequential LASER ART and CRISPR treatments eliminate HIV-1 in a subset of infected humanized mice
Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from
infected cells and tissues. Here, sequential long-acting slow-effective release antiviral …
infected cells and tissues. Here, sequential long-acting slow-effective release antiviral …
Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells
DM Stranford, LM Simons, KE Berman… - Nature biomedical …, 2024 - nature.com
The genetic modification of T cells has advanced cellular immunotherapies, yet the delivery
of biologics specifically to T cells remains challenging. Here we report a suite of methods for …
of biologics specifically to T cells remains challenging. Here we report a suite of methods for …
Application of CRISPR/Cas9-based gene editing in HIV-1/AIDS therapy
Q Xiao, D Guo, S Chen - Frontiers in cellular and infection …, 2019 - frontiersin.org
Despite the fact that great efforts have been made in the prevention and therapy of HIV-1
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …
CRISPR based editing of SIV proviral DNA in ART treated non-human primates
Elimination of HIV DNA from infected individuals remains a challenge in medicine. Here, we
demonstrate that intravenous inoculation of SIV-infected macaques, a well-accepted non …
demonstrate that intravenous inoculation of SIV-infected macaques, a well-accepted non …
[HTML][HTML] In vivo genome editing in animals using AAV-CRISPR system: applications to translational research of human disease
Adeno-associated virus (AAV) has shown promising therapeutic efficacy with a good safety
profile in a wide range of animal models and human clinical trials. With the advent of …
profile in a wide range of animal models and human clinical trials. With the advent of …
CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice
D Stone, KR Long, MA Loprieno, HSDS Feelixge… - … Therapy-Methods & …, 2021 - cell.com
Chronic hepatitis B virus (HBV) infection is a major public health problem. New treatment
approaches are needed because current treatments do not target covalently closed circular …
approaches are needed because current treatments do not target covalently closed circular …