Targeting renin–angiotensin system against Alzheimer's disease

AK Gebre, BM Altaye, TM Atey, KB Tuem… - Frontiers in …, 2018 - frontiersin.org
Renin Angiotensin System (RAS) is a hormonal system that regulates blood pressure and
fluid balance through a coordinated action of renal, cardiovascular, and central nervous …

Role of brain renin–angiotensin system in depression: a new perspective

NH Ali, HM Al‐Kuraishy, AI Al‐Gareeb… - CNS Neuroscience …, 2024 - Wiley Online Library
Depression is a mood disorder characterized by abnormal thoughts. The pathophysiology of
depression is related to the deficiency of serotonin (5HT), which is derived from tryptophan …

Recent advances in the endogenous brain renin-angiotensin system and drugs acting on it

A Urmila, P Rashmi, G Nilam… - Journal of the Renin …, 2021 - journals.sagepub.com
The RAS (renin-angiotensin system) is the part of the endocrine system that plays a prime
role in the control of essential hypertension. Since the discovery of brain RAS in the …

Brain angiotensin II and angiotensin IV receptors as potential Alzheimer's disease therapeutic targets

J Royea, E Hamel - Geroscience, 2020 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder that is multifactorial in nature. Yet,
despite being the most common form of dementia in the elderly, AD's primary cause remains …

COVID-19, ferrosenescence and neurodegeneration, a mini-review

A Sfera, C Osorio, G Maguire, L Rahman… - Progress in Neuro …, 2021 - Elsevier
Exacerbation of cognitive, motor and nonmotor symptoms have been described in critically
ill COVID-19 patients, indicating that, like prior pandemics, neurodegenerative sequelae …

Interplay between the renin angiotensin system and oxidative stress contributes to alcohol addiction by stimulating dopamine accumulation in the mesolimbic pathway

M Sun, C Wu, L Liu, L Gu, Z Wang, F Xu… - Biochemical Pharmacology, 2023 - Elsevier
The brain renin–angiotensin system (RAS) has recently been implicated in the development
of substance abuse and addiction. However, the integrative roles of the two counter …

A diagnostic model for Parkinson's disease based on circadian rhythm-related genes

L Wang, Y Bao, X Duan, H Li, H Ding, F Yu… - Journal of Translational …, 2024 - Springer
Background Circadian rhythm (CR) disturbance is intricately associated with Parkinson's
disease (PD). However, the involvement of CR-related mechanisms in the pathogenesis and …

Antihypertensive medication class and the risk of dementia and cognitive decline in older adults: a secondary analysis of the prospective HELIAD Cohort

I Liampas, A Hatzimanolis, V Siokas… - Journal of …, 2022 - content.iospress.com
Background: It is unclear whether the main antihypertensive medication classes (diuretics,
calcium channel blockers, betablockers, angiotensin converting enzyme inhibitors, and …

Role of the renin-angiotensin-aldosterone system in various disease processes: An overview

V Gelen, A Kükürt, E Şengül - Renin-Angiotensin Aldosterone …, 2021 - books.google.com
The renin-angiotensin-aldosterone system is a physiological system that plays an important
role in the regulation of blood pressure and body water-electrolyte balance, in which the …

Telmisartan Restricts Chikungunya Virus Infection In Vitro and In Vivo through the AT1/PPAR-γ/MAPKs Pathways

S De, P Mamidi, S Ghosh, SS Keshry… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Chikungunya virus (CHIKV) has reemerged as a global public health threat. The
inflammatory pathways of the renin-angiotensin system (RAS) and peroxisome proliferator …