Histatin 5 Metallopeptides and Their Potential against Candida albicans Pathogenicity and Drug Resistance

GVS Zolin, FH Fonseca, CR Zambom, SS Garrido - Biomolecules, 2021 - mdpi.com
Usually caused by Candida albicans, buccal candidiasis begins with the morphological
transition between yeast and hyphal cells. Over time and without the correct treatment, it can …

The antimicrobial and immunomodulatory effects of Ionophores for the treatment of human infection

G Li, DMP De Oliveira, MJ Walker - Journal of Inorganic Biochemistry, 2022 - Elsevier
Ionophores are a diverse class of synthetic and naturally occurring ion transporter
compounds which demonstrate both direct and in-direct antimicrobial properties against a …

The influence of a copper efflux pump in Histoplasma capsulatum virulence

D Moraes, GB Tristão, CA Rappleye, SC Ray… - The FEBS …, 2024 - Wiley Online Library
During the infectious process, pathogenic microorganisms must obtain nutrients from the
host in order to survive and proliferate. These nutritional sources include the metallic nutrient …

Molecular characterization of siderophore biosynthesis in Paracoccidioides brasiliensis

MG Silva, JS De Curcio, MG Silva-Bailão, RM Lima… - IMA fungus, 2020 - Springer
Iron is an essential nutrient for all organisms. For pathogenic fungi, iron is essential for the
success of infection. Thus, these organisms have developed high affinity iron uptake …

Identification of membrane proteome of Paracoccidioides lutzii and its regulation by zinc

JS de Curcio, MG Silva, MG Silva Bailão… - Future science …, 2017 - Taylor & Francis
Aim: During infection development in the host, Paracoccidioides spp. faces the deprivation
of micronutrients, a mechanism called nutritional immunity. This condition induces the …

Global Molecular Response of Paracoccidioides brasiliensis to Zinc Deprivation: Analyses at Transcript, Protein and MicroRNA Levels

LA Mesquita, AM Bailão, JS de Curcio, KLP da Silva… - Journal of Fungi, 2023 - mdpi.com
Zinc is one of the main micronutrients for all organisms. One of the defense mechanisms
used by the host includes the sequestration of metals used in fungal metabolism, such as …

A proteomic view of the response of Paracoccidioides yeast cells to zinc deprivation

AFA Parente, TCV de Rezende, KP De Castro… - Fungal biology, 2013 - Elsevier
Zinc plays a critical role in a diverse array of biochemical processes. However, an excess of
zinc is deleterious to cells; therefore, cells require finely tuned homeostatic mechanisms to …

Paracoccidioides spp. ferrous and ferric iron assimilation pathways

EFLC Bailão, PS Lima, MG Silva-Bailão… - Frontiers in …, 2015 - frontiersin.org
Iron is an essential micronutrient for almost all organisms, including fungi. Usually, fungi can
uptake iron through receptor-mediated internalization of a siderophore or heme, and/or …

miRNAs regulate the metabolic adaptation of Paracoccidioides brasiliensis during copper deprivation

DLA Dos Santos, JS de Curcio, E Novaes… - Microbes and …, 2024 - Elsevier
Copper is an essential metal for cellular processes such as detoxification of reactive oxygen
species, oxidative phosphorylation, and iron uptake. However, during infection, the host …

The study of iron‐ and copper‐binding proteome of Fusarium oxysporum and its effector candidates

AS Kushwah, H Dixit, V Upadhyay… - Proteins: Structure …, 2024 - Wiley Online Library
Fusarium oxysporum f. sp. lycopersici is a phytopathogen which causes vascular wilt
disease in tomato plants. The survival tactics of both pathogens and hosts depend on …