Irresponsible research practices damaging the value of science has been an increasing
concern among researchers, but previous work failed to estimate the prevalence of all forms …

The frequency with which scientists fabricate and falsify data, or commit other forms of
scientific misconduct is a matter of controversy. Many surveys have asked scientists directly …

Cases of clear scientific misconduct have received significant media attention recently, but
less flagrantly questionable research practices may be more prevalent and, ultimately, more …

Reporting bias represents a major problem in the assessment of health care interventions.
Several prominent cases have been described in the literature, for example, in the reporting …

Three recent systematic reviews have shown that pharmaceutical industry funding of clinical
trials is strongly associated with pro-industry results. This article builds on those analyses …

Objective To assess the efficacy and safety of dual sodium glucose cotransporter (SGLT) 1/2
inhibitor sotagliflozin in type 1 diabetes mellitus. Design Meta-analysis of randomised …

Background Sodium-glucose cotransporter-2 (SGLT2) inhibitors (SGLT2i) showed benefits
in type 1 diabetes mellitus (T1DM), but the risk of diabetic ketoacidosis (DKA) limits their use …

Integrity in research is fundamental to the advancement of knowledge, for the public's
support of research, and the autonomy of the academic profession. Misconduct in the forms …

Background: Pharmaceutical companies fund the vast majority of the clinical research that is
undertaken on medications but face a conflict of interest between producing good science …

Background In recent years, a number of studies have shown that clinical drug trials
financed by pharmaceutical companies yield favorable results for company products more …