The therapeutic and diagnostic effects of nanoparticles highly depend on the efficiency of
their delivery to targeted tissues, such as tumors. The size of nanoparticles, among other …

Highlights•Nucleotide metabolism.•Tumor microenvironment.•Immune cells.•Cancer
therapy.•Immunotherapy.Nucleotide metabolism plays a crucial role in the regulation of the …

Background Adenosine is a potent immunosuppressant whose levels in the tumor
microenvironment (TME) are often much higher than those in normal tissues. Binding of …

Large amounts of adenosine triphosphate (ATP), a natural P2X7 receptor activator, are
released during colorectal carcinogenesis. P2X7 receptor activation regulates the activity of …

Aptamers are emerging as promising molecular tools in cancer‐targeted theranostics.
Improving their in vivo stability has been a critical issue in promoting clinical translation, but …

Extracellular adenosine triphosphate (ATP) is one of the most abundant biochemical
constitutes within the stem cell microenvironment and is postulated to play critical roles in …

Introduction Cervical cancer threatens women's health seriously. In recent years, the
incidence of cervical cancer is on the rise, and the age of onset tends to be younger …

Purine nucleotides and nucleosides are involved in various human physiological and
pathological mechanisms. The pathological deregulation of purinergic signaling contributes …

Background: Liver cirrhosis is the common end-stage of liver disease which lacks effective
treatment, thus studies to determine prevention targets are an urgent need. The intestinal …

Purpose Loss of expression of DLG2 has been identified in a number of cancers to
contribute to the disease by resulting in increased tumor cell proliferation and poor survival …