Recent evidence supports the notion that mitochondrial metabolism is necessary for the
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …

The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

Steady-state hematopoietic stem cells'(HSCs) self-renewal and differentiation toward their
mature progeny in the adult bone marrow is tightly regulated by cues from the …

Bone marrow endothelial cells (BMECs) form a network of blood vessels that regulate both
leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenance …

Recent advances have highlighted the ability of hematopoietic stem and progenitor cells in
the bone marrow to sense peripheral inflammation or infection and adapt through increased …

Acute kidney injury (AKI) is a global public health concern associated with high morbidity,
mortality, and healthcare costs. Other than dialysis, no therapeutic interventions reliably …

The transition of AKI to CKD has major clinical significance. As reviewed here, recent studies
show that a subpopulation of dedifferentiated, proliferating tubules recovering from AKI …

In adult mammals, hematopoietic stem cells (HSCs) are defined by their abilities to self‐
renew and to differentiate to form all blood cell lineages. These rare multipotent cells occupy …

Host microbiota crosstalk is essential for the production and functional modulation of blood-
cell lineages. Whether, and if so how, the microbiota influences hematopoietic stem cells …