The most recent and non-invasive approach for studying early-stage biomarkers is liquid
biopsy. This implies the extraction and analysis of non-solid biological tissues (serum …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the loss of upper and lower motor neurons. Presently, three FDA-approved drugs are …

Traditionally, transfer RNAs (tRNAs) specifically decoded messenger RNA (mRNA) and
participated in protein translation. tRNA-derived fragments (tRFs), also known as tRNA …

Background and objectives We examined miRNA biomarkers for ALS extracted from
extracellular vesicles in blood samples using a large and diverse patient and control …

Macrophages are important antigen presenting cells which can release extracellular
vesicles (EVs) carrying functional cargo including non‐coding RNAs. Macrophages can be …

Background Alzheimer's disease (AD) diagnosis relies on clinical symptoms complemented
with biological biomarkers, the Amyloid Tau Neurodegeneration (ATN) framework. Small …

Prion diseases are transmissible spongiform encephalopathies (TSEs) caused by a
conformational conversion of the native cellular prion protein (PrPC) to an abnormal …

Frailty is an aging related condition, which has been defined as a state of enhanced
vulnerability to stressors, leading to a limited capacity to meet homeostatic demands …

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disorder with
no cure available and limited treatment options. ALS is a highly heterogeneous disease …

Introduction Objective biomarkers for the fatal neurodegenerative disease amyotrophic
lateral sclerosis or motor neuron disease (ALS/MND) are critical for diagnosis, drug …