Controlling natural killer cell responses: integration of signals for activation and inhibition
Understanding how signals are integrated to control natural killer (NK) cell responsiveness
in the absence of antigen-specific receptors has been a challenge, but recent work has …
in the absence of antigen-specific receptors has been a challenge, but recent work has …
Recognition and regulation of T cells by NK cells
K Pallmer, A Oxenius - Frontiers in immunology, 2016 - frontiersin.org
Regulation of T cell responses by innate lymphoid cells (ILCs) is increasingly documented
and studied. Direct or indirect crosstalk between ILCs and T cells early during and after T …
and studied. Direct or indirect crosstalk between ILCs and T cells early during and after T …
NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non–major histocompatibility complex–restricted tumor …
After culture in interleukin (IL)-2, natural killer (NK) cells acquire an increased capability of
mediating non–major histocompatibility complex (MHC)–restricted tumor cell lysis. This may …
mediating non–major histocompatibility complex (MHC)–restricted tumor cell lysis. This may …
Current perspectives of natural killer cell education by MHC class I molecules
From the early days of natural killer (NK) cell research, it was clear that MHC genes
controlled the specificity of mouse NK cell-dependent responses, such as the ability to reject …
controlled the specificity of mouse NK cell-dependent responses, such as the ability to reject …
NK cells, MHC class I molecules and the missing self
K Kärre - Scandinavian journal of immunology, 2002 - Wiley Online Library
This article is based on a lecture presented at the Novartis Prize ceremony at the
International Congress of Immunology in July 2001. It gives a personal and historical …
International Congress of Immunology in July 2001. It gives a personal and historical …
The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells
P Brodin, T Lakshmikanth, S Johansson… - Blood, The Journal …, 2009 - ashpublications.org
Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex
(MHC) class I. If self-MHC is down-regulated or absent, lack of inhibition triggers “missing …
(MHC) class I. If self-MHC is down-regulated or absent, lack of inhibition triggers “missing …
The speed of change: towards a discontinuity theory of immunity?
Immunology—though deeply experimental in everyday practice—is also a theoretical
discipline. Recent advances in the understanding of innate immunity, how it is triggered and …
discipline. Recent advances in the understanding of innate immunity, how it is triggered and …
MHC class I–deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I–sufficient environment
JM Elliott, JA Wahle, WM Yokoyama - Journal of Experimental Medicine, 2010 - rupress.org
In MHC class I–deficient hosts, natural killer (NK) cells are hyporesponsive to cross-linking
of activation receptors. Functional competence requires engagement of a self–major …
of activation receptors. Functional competence requires engagement of a self–major …
Fas-mediated cytotoxicity by freshly isolated natural killer cells.
The expression of Fas ligand on natural killer (NK) cells and Fas-mediated cytotoxicity by NK
cells was investigated. Fas ligand mRNA was expressed in freshly isolated NK cells but not …
cells was investigated. Fas ligand mRNA was expressed in freshly isolated NK cells but not …
Major histocompatibility complex class I‐specific receptors on human natural killer and T lymphocytes
Human NK cells express several specialized inhibitory receptors that recognize major
histocompatibility complex (MHC) class I molecules expressed on normal cells. The lack of …
histocompatibility complex (MHC) class I molecules expressed on normal cells. The lack of …