Hydrocephalus: historical analysis and considerations for treatment

A Hochstetler, J Raskin, BL Blazer-Yost - European journal of medical …, 2022 - Springer
Hydrocephalus is a serious condition that affects patients of all ages, resulting from a
multitude of causes. While the etiologies of hydrocephalus are numerous, many of the acute …

Choroid plexus pathophysiology

Y Courtney, A Hochstetler… - Annual Review of …, 2024 - annualreviews.org
This review examines the crucial roles of the choroid plexus (ChP) in central nervous system
(CNS) pathology, emphasizing its involvement in disease mechanisms and therapeutic …

Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1

TL Toft-Bertelsen, D Barbuskaite, EK Heerfordt… - Fluids and barriers of the …, 2022 - Springer
Background A range of neurological pathologies may lead to secondary hydrocephalus.
Treatment has largely been limited to surgical cerebrospinal fluid (CSF) diversion, as …

Boundary conditions investigation to improve computer simulation of cerebrospinal fluid dynamics in hydrocephalus patients

S Gholampour, N Fatouraee - Communications biology, 2021 - nature.com
Three-D head geometrical models of eight healthy subjects and 11 hydrocephalus patients
were built using their CINE phase-contrast MRI data and used for computer simulations …

[HTML][HTML] Mechanisms of cerebrospinal fluid and brain interstitial fluid production

J Xiang, Y Hua, G Xi, RF Keep - Neurobiology of disease, 2023 - Elsevier
Fluid homeostasis is fundamental for brain function with cerebral edema and hydrocephalus
both being major neurological conditions. Fluid movement from blood into brain is one …

TRPV4 antagonists: A patent review (2015–2020)

BG Lawhorn, EJ Brnardic, DJ Behm - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Transient receptor potential vanilloid 4 (TRPV4) is an ion channel that is widely
expressed and is activated by numerous chemical, osmotic and mechanical stimuli. By …

[HTML][HTML] Dual function of the choroid plexus: Cerebrospinal fluid production and control of brain ion homeostasis

N MacAulay, TL Toft-Bertelsen - Cell Calcium, 2023 - Elsevier
The choroid plexus is a small monolayered epithelium located in the brain ventricles and
serves to secrete the cerebrospinal fluid (CSF) that envelops the brain and fills the central …

TRPV4: A trigger of pathological RhoA activation in neurological disease

AM Bagnell, CJ Sumner, BA McCray - BioEssays, 2022 - Wiley Online Library
Transient receptor potential vanilloid 4 (TRPV4), a member of the TRP superfamily, is a
broadly expressed, cell surface‐localized cation channel that is activated by a variety of …

Hydrodynamic comparison of shunt and endoscopic third ventriculostomy in adult hydrocephalus using in vitro models and fluid-structure interaction simulation

S Gholampour, M Bahmani - Computer Methods and Programs in …, 2021 - Elsevier
Objective The comparison of the efficiency of shunt placement and endoscopic third
ventriculostomy (ETV) in treating of adult hydrocephalus patients with various intensities and …

Characterization of TRPV4-mediated signaling pathways in an optimized human choroid plexus epithelial cell line

L Hulme, A Hochstetler, C Schwerk… - … of Physiology-Cell …, 2022 - journals.physiology.org
The objectives of these studies were twofold: 1) to characterize the human choroid plexus
papilloma (HIBCPP) cell line as a model of the blood-cerebrospinal fluid barrier (BCSFB) via …