Genetics of diffuse large B-cell lymphoma

L Pasqualucci, R Dalla-Favera - Blood, The Journal of the …, 2018 - ashpublications.org
Diffuse large B-cell lymphoma (DLBCL), the most frequent subtype of lymphoid malignancy,
remains a significant clinical challenge, as∼ 30% of patients are not cured. Over the past …

Roles of BCL6 in normal and transformed germinal center B cells

K Basso, R Dalla‐Favera - Immunological reviews, 2012 - Wiley Online Library
BCL6 is a transcriptional repressor required in mature B cells during the germinal center
(GC) reaction. Multiple mechanisms act coordinately to timely modulate BCL6 expression at …

Rewiring cancer drivers to activate apoptosis

S Gourisankar, A Krokhotin, W Ji, X Liu, CY Chang… - Nature, 2023 - nature.com
Genes that drive the proliferation, survival, invasion and metastasis of malignant cells have
been identified for many human cancers,,–. Independent studies have identified cell death …

Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray

CP Hans, DD Weisenburger, TC Greiner… - Blood, 2004 - ashpublications.org
Diffuse large B-cell lymphoma (DLBCL) can be divided into prognostically important
subgroups with germinal center B-cell–like (GCB), activated B-cell–like (ABC), and type 3 …

Pathogenesis of human B cell lymphomas

AL Shaffer III, RM Young… - Annual review of …, 2012 - annualreviews.org
The mechanisms that drive normal B cell differentiation and activation are frequently
subverted by B cell lymphomas for their unlimited growth and survival. B cells are …

BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis

K Basso, R Dalla-Favera - Advances in immunology, 2010 - Elsevier
BCL6 is a transcriptional repressor which has emerged as a critical regulator of germinal
centers (GC), the sites where B cells are selected based on the production of antibodies with …

Pathogenesis of non-Hodgkin's lymphoma

H Nogai, B Dörken, G Lenz - Journal of Clinical Oncology, 2011 - ascopubs.org
The understanding of the molecular pathogenesis of non-Hodgkin's lymphomas (NHL) has
significantly improved in recent years. Advances in molecular biology and genetics lead to …

The genetic landscape of diffuse large B-cell lymphoma

L Pasqualucci, R Dalla-Favera - Seminars in hematology, 2015 - Elsevier
Diffuse large B-cell lymphoma (DLBCL), the most common lymphoid malignancy in the
western world, is an aggressive disease that remains incurable in approximately 30% of …

[HTML][HTML] A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma

M Saito, J Gao, K Basso, Y Kitagawa, PM Smith… - Cancer cell, 2007 - cell.com
The BCL6 proto-oncogene encodes a transcriptional repressor necessary for the
development of germinal centers (GCs) and directly implicated in lymphomagenesis. Post …

Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation

C Tunyaplin, AL Shaffer… - The Journal of …, 2004 - journals.aai.org
We have identified two intronic regions of mouse prdm1, the gene encoding B lymphocyte-
induced maturation protein-1 (Blimp-1), which confer transcriptional repression in response …