Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Background: It has been four decades since protein S-glutathionylation was proposed to
serve as a regulator of cell metabolism. Since then, this redox-sensitive covalent …

BACKGROUND: The cardiac-protective role of GSNOR (S-nitrosoglutathione reductase) in
the cytoplasm, as a denitrosylase enzyme of S-nitrosylation, has been reported in cardiac …

Redox post-translational modifications are derived from fluctuations in the redox potential
and modulate protein function, localization, activity and structure. Amongst the oxidative …

Tumor cells can develop resistance to cell death which is divided into necrosis and
programmed cell death (PCD). PCD, including apoptosis, autophagy, ferroptosis, pyroptosis …

Melatonin and several of its metabolites are interfering with reactive nitrogen. With the notion
of prevailing melatonin formation in tissues that exceeds by far the quantities in blood …

S-nitrosylation is a selective and reversible post-translational modification of protein thiols by
nitric oxide (NO), which is a bioactive signaling molecule, to exert a variety of effects. These …

Pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) are vital
sources of hydrogen peroxide (H 2 O 2) and key sites for redox regulation. Here, we report …

The prevalence of NAFLD (non-alcoholic fatty liver disease) is a rapidly increasing problem,
affecting a huge population around the globe. However, CVDs (cardiovascular diseases) …

A hybrid cluster (HC) is a 4Fe cluster with both sulfur and oxygen bridges. Hybrid cluster
proteins (Hcps) contain two 4Fe clusters, a one electron transferring iron-sulfur cluster and a …