[HTML][HTML] Role of phytochemicals in cancer chemoprevention: Insights

BP George, R Chandran, H Abrahamse - Antioxidants, 2021 - mdpi.com
Cancer is a condition where the body cells multiply in an uncontrollable manner.
Chemoprevention of cancer is a broad term that describes the involvement of external …

Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance

MK Ediriweera, KH Tennekoon… - Seminars in cancer …, 2019 - Elsevier
Ovarian cancer (OC) is a lethal gynecological cancer. The phosphatidylinositol 3-kinase
(PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway plays an important …

Targeting the PI3K/AKT/mTOR signaling pathway in lung cancer: an update regarding potential drugs and natural products

Iksen, S Pothongsrisit, V Pongrakhananon - Molecules, 2021 - mdpi.com
Lung cancer is one of the most common cancers and has a high mortality rate. Due to its
high incidence, the clinical management of the disease remains a major challenge. Several …

PI3K-AKT-mTOR and NFκB pathways in ovarian cancer: implications for targeted therapeutics

A Ghoneum, N Said - Cancers, 2019 - mdpi.com
Ovarian cancer is the most lethal gynecologic malignancy in the United States, with an
estimated 22,530 new cases and 13,980 deaths in 2019. Recent studies have indicated that …

Flavonoids against the Warburg phenotype—Concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

M Samec, A Liskova, L Koklesova, SM Samuel, K Zhai… - Epma Journal, 2020 - Springer
The Warburg effect is characterised by increased glucose uptake and lactate secretion in
cancer cells resulting from metabolic transformation in tumour tissue. The corresponding …

Role and mechanism of autophagy‐regulating factors in tumorigenesis and drug resistance

RM Usman, F Razzaq, A Akbar… - Asia‐Pacific Journal …, 2021 - Wiley Online Library
A hallmark feature of tumorigenesis is uncontrolled cell division. Autophagy is regulated by
more than 30 genes and it is one of several mechanisms by which cells maintain …

Disruption of the gut microbiota confers cisplatin resistance in epithelial ovarian cancer

LM Chambers, EL Esakov Rhoades, R Bharti, C Braley… - Cancer research, 2022 - AACR
Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer death. Despite
initial responses to intervention, up to 80% of patient tumors recur and require additional …

Phytochemicals as chemo-preventive agents and signaling molecule modulators: current role in cancer therapeutics and inflammation

MB Ahmed, SU Islam, AAA Alghamdi… - International Journal of …, 2022 - mdpi.com
Cancer is one of the deadliest non communicable diseases. Numerous anticancer
medications have been developed to target the molecular pathways driving cancer …

Apigenin role as cell-signaling pathways modulator: implications in cancer prevention and treatment

Z Javed, H Sadia, MJ Iqbal, S Shamas, K Malik… - Cancer Cell …, 2021 - Springer
Cancer is a complex disease orchestrated by various extrinsic and intrinsic pathways. In
recent years, there has been a keen interest towards the development of natural extracts …

[HTML][HTML] Low grade serous ovarian cancer–a rare disease with increasing therapeutic options

TA Zwimpfer, O Tal, F Geissler, R Coelho… - Cancer Treatment …, 2023 - Elsevier
High-grade serous ovarian cancers (HGSOCs) most commonly arise from the fimbrial end of
the fallopian tube and harbor TP53 gene mutations. In contrast, low-grade serous ovarian …