Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)
Inhibitors of apoptosis (IAPs) are a family of proteins that play a significant role in the control
of programmed cell death (PCD). PCD is essential to maintain healthy cell turnover within …
of programmed cell death (PCD). PCD is essential to maintain healthy cell turnover within …
Viral vectors: a look back and ahead on gene transfer technology
L Vannucci, M Lai, F Chiuppesi, L Ceccherini-Nelli… - New …, 2013 - arpi.unipi.it
No matter what their origin, strain and family, viruses have evolved exquisite strategies to
reach and penetrate specific target cells where they hijack the cellular machinery to express …
reach and penetrate specific target cells where they hijack the cellular machinery to express …
[HTML][HTML] Glutamate, glutamate receptors, and downstream signaling pathways
SS Willard, S Koochekpour - International journal of biological …, 2013 - ncbi.nlm.nih.gov
Glutamate is a nonessential amino acid, a major bioenergetic substrate for proliferating
normal and neoplastic cells, and an excitatory neurotransmitter that is actively involved in …
normal and neoplastic cells, and an excitatory neurotransmitter that is actively involved in …
Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance
P Dahan, J Martinez Gala, C Delmas, S Monferran… - Cell death & …, 2014 - nature.com
Glioblastomas (GBM) are some bad prognosis brain tumors despite a conventional
treatment associating surgical resection and subsequent radio-chemotherapy. Among these …
treatment associating surgical resection and subsequent radio-chemotherapy. Among these …
Emerging importance of survivin in stem cells and cancer: the development of new cancer therapeutics
Survivin is one of the rare proteins that is differentially expressed in normal and cancer cells
and is directly or indirectly involved in numerous pathways required for tumor maintenance …
and is directly or indirectly involved in numerous pathways required for tumor maintenance …
Cancer multidrug resistance: mechanisms involved and strategies for circumvention using a drug delivery system
G Kibria, H Hatakeyama, H Harashima - Archives of pharmacal research, 2014 - Springer
Multidrug resistance (MDR), the principal mechanism by which many cancers develop
resistance to chemotherapy, is one of the major obstacles to the successful clinical treatment …
resistance to chemotherapy, is one of the major obstacles to the successful clinical treatment …
The role of inflammation in cadmium nephrotoxicity: NF-κB comes into view
Kidney diseases are major health problem and understanding the underlined mechanisms
that lead to kidney diseases are critical research points with a marked potential impact on …
that lead to kidney diseases are critical research points with a marked potential impact on …
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription
Early in cancer development, tumour cells express vascular endothelial growth factor
(VEGF), a secreted molecule that is important in all stages of angiogenesis, an essential …
(VEGF), a secreted molecule that is important in all stages of angiogenesis, an essential …
Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway
L Tao, G Huang, R Wang, Y Pan, Z He, X Chu… - Scientific reports, 2016 - nature.com
Cancer-associated fibroblasts (CAF) are recognized as one of the key determinants in the
malignant progression of lung adenocarcinoma. And its contributions to chemoresistance …
malignant progression of lung adenocarcinoma. And its contributions to chemoresistance …
Targeting of erbB3 receptor to overcome resistance in cancer treatment
The erbB receptors, including the epidermal growth factor receptor (EGFR), erbB2 (also
known as HER2/neu), erbB3 (or HER3), and erbB4 (or HER4), are often aberrantly activated …
known as HER2/neu), erbB3 (or HER3), and erbB4 (or HER4), are often aberrantly activated …