The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

The GATA family of transcription factors is of crucial importance during embryonic
development, playing complex and widespread roles in cell fate decisions and tissue …

Germline GATA2 mutations cause cellular deficiencies with high propensity for myeloid
disease. We investigated 426 children and adolescents with primary myelodysplastic …

Transplantation of hematopoietic stem cells (HSCs) from human umbilical cord blood
(hUCB) holds great promise for treating a broad spectrum of hematological disorders …

Heterozygous familial or sporadic GATA 2 mutations cause a multifaceted disorder,
encompassing susceptibility to infection, pulmonary dysfunction, autoimmunity …

Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently
been shown to underlie a range of clinical phenotypes, including Emberger syndrome, a …

Knowledge of the key transcription factors that drive hematopoietic stem cell (HSC)
generation is of particular importance for current hematopoietic regenerative approaches …

Increasing awareness about germline predisposition and the widespread application of
unbiased whole exome sequencing contributed to the discovery of new clinical entities with …

Chromosomal inversion between 3q21 and 3q26 results in high-risk acute myeloid leukemia
(AML). In this study, we identified a mechanism whereby a GATA2 distal hematopoietic …

Previous reports of GATA2 mutations have focused on the coding region of the gene or full
gene deletions. We recently identified 2 patients with novel insertion/deletion mutations …