We discuss the tripartite pathophysiological circuit of inflammatory bowel disease (IBD),
involving the intestinal microbiota, barrier function, and immune system. Dysfunction in each …

Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease that can
involve any part of the gastrointestinal tract. It includes two main disorders: Crohn's disease …

Genome-wide association studies provide a powerful means of identifying loci and genes
contributing to disease, but in many cases, the related cell types/states through which genes …

Inflammatory Bowel Diseases (IBD) are chronic inflammatory disorders, where epithelial
defects drive, at least in part, some of the pathology. We reconstituted human intestinal …

The incidence of esophageal adenocarcinoma (EAC) has increased in recent decades, and
its 5-year survival rate is less than 20%. As a well-established precursor, patients with …

Spurred on by ever-evolving developments in analytical methodology, the microbiome, and
the gut microbiome in particular, has become the hot topic in biomedical research. Ingenious …

Very early onset inflammatory bowel disease (VEO-IBD) is a unique disease entity with a
complex genetic susceptibility in affected patients. Next-generation gene sequencing …

Dysbiosis of gut microbiota occurs in many human chronic immune-mediated diseases,
such as inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC) …

Germline telomere maintenance defects are associated with an increased incidence of
inflammatory diseases in humans, yet whether and how telomere dysfunction causes …

The rate of pediatric inflammatory bowel disease (IBD) has been increasing over the last
decade and this increase has occurred most rapidly in the youngest children diagnosed< 6 …