Design and Optimization of an α-Helical Bundle Dimer Cell-Penetrating Peptide for In Vivo Drug Delivery
S Hyun, D Kim, J Cho, D Jeong… - Bioconjugate …, 2022 - ACS Publications
To deliver membrane-impermeable drugs into eukaryotic cells, a lot of cell-penetrating
peptides (CPPs) were discovered. Previously we designed an amphipathic α-helical peptide …
peptides (CPPs) were discovered. Previously we designed an amphipathic α-helical peptide …
Determination of absolute orientation of protein α-helices at interfaces using phase-resolved sum frequency generation spectroscopy
Understanding the structure of proteins at surfaces is key in fields such as biomaterials
research, biosensor design, membrane biophysics, and drug design. A particularly important …
research, biosensor design, membrane biophysics, and drug design. A particularly important …
De Novo Design and Characterization of Amphiphilic Peptides with Basic Side Chains for Tailored Interfacial Chemistries
Lysine–leucine (LK) peptides have been used as model systems and platforms for 2D
material design for decades. LK peptides are amphiphilic sequences designed to bind and …
material design for decades. LK peptides are amphiphilic sequences designed to bind and …
[HTML][HTML] Predicting the orientation of protein G B1 on hydrophobic surfaces using Monte Carlo simulations
A Monte Carlo algorithm was developed to predict the most likely orientations of protein G
B1, an immunoglobulin G (IgG) antibody-binding domain of protein G, adsorbed onto a …
B1, an immunoglobulin G (IgG) antibody-binding domain of protein G, adsorbed onto a …
Amphiphilic peptide binding on crystalline vs. amorphous silica from molecular dynamics simulations
J Sampath, J Pfaendtner - Molecular Physics, 2019 - Taylor & Francis
The leucine-lysine amphiphilic peptide LKα14 has been used to study fundamental driving
forces in processes such as peptide-surface binding and biomineralization. Here, we …
forces in processes such as peptide-surface binding and biomineralization. Here, we …
Oligomer formation propensities of dimeric bundle peptides correlate with cell penetration abilities
S Hyun, Y Lee, SM Jin, J Cho, J Park… - ACS Central …, 2018 - ACS Publications
LK-3, an amphipathic dimeric peptide linked by two disulfide bonds, and related isomeric
bundles were synthesized, and their cell penetrating abilities were investigated. The …
bundles were synthesized, and their cell penetrating abilities were investigated. The …
De Novo Designed Cell-Penetrating Peptide Self-Assembly Featuring Distinctive Tertiary Structure
J Park, E Yamashita, J Yu, SJ Lee, S Hyun - ACS omega, 2024 - ACS Publications
Recent attention has focused on the de novo design of proteins, paralleling advancements
in biopharmaceuticals. Achieving protein designs with both structure and function poses a …
in biopharmaceuticals. Achieving protein designs with both structure and function poses a …
Acetylation dictates the morphology of nanophase biosilica precipitated by a 14‐amino acid leucine–lysine peptide
N‐terminal acetylation is a commonly used modification technique for synthetic peptides,
mostly applied for reasons of enhanced stability, and in many cases regarded as …
mostly applied for reasons of enhanced stability, and in many cases regarded as …
The air-water interface stabilizes α-helical conformations of the insulin B-chain
DL Cheung - The Journal of Chemical Physics, 2019 - pubs.aip.org
Adsorption of proteins onto liquid interfaces, such as the air-water interface, often leads to
changes in the protein conformation. This can lead to changes in protein assembly behavior …
changes in the protein conformation. This can lead to changes in protein assembly behavior …
Representing environment-induced helix-coil transitions in a coarse grained peptide model
Coarse grained (CG) models are widely used in studying peptide self-assembly and
nanostructure formation. One of the recurrent challenges in CG modeling is the problem of …
nanostructure formation. One of the recurrent challenges in CG modeling is the problem of …