Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

Over the last several decades, it has become clear that epigenetic abnormalities may be one
of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play …

There have been major advances in our understanding of the cellular and molecular biology
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …

Platinum-based chemotherapy, including cisplatin, carboplatin, and oxaliplatin, is prescribed
to 10-20% of all cancer patients. Unfortunately, platinum resistance develops in a significant …

A plethora of groundbreaking studies have demonstrated the importance of chromatin-
associated proteins and post-translational modifications of histones, proteins and DNA (so …

Reversible acetylation of histone and non-histone proteins is one of the most abundant post-
translational modifications in eukaryotic cells. Protein acetylation and deacetylation are …

Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

Spinal cord injury (SCI) is a severe neurological disease; however, there is no effective
treatment for spinal cord injury. Neuroinflammation involves the activation of resident …

Signal transducer and activator of transcription (STAT) 1 is part of the Janus kinase
(JAK)/STAT signalling cascade and is best known for its essential role in mediating …

In recent years it has become widely recognized that histone modification plays a pivotal
role in controlling gene expression and is involved in a wide spectrum of disease regulation …