A review on the role of bicarbonate and proton transporters during sperm capacitation in mammals
A Delgado-Bermúdez, M Yeste, S Bonet… - International Journal of …, 2022 - mdpi.com
Alkalinization of sperm cytosol is essential for plasma membrane hyperpolarization,
hyperactivation of motility, and acrosomal exocytosis during sperm capacitation in mammals …
hyperactivation of motility, and acrosomal exocytosis during sperm capacitation in mammals …
Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation
S Young, C Schiffer, A Wagner, J Patz… - The Journal of …, 2024 - Am Soc Clin Investig
The infertility of many couples rests on an enigmatic dysfunction of the man's sperm. To gain
insight into the underlying pathomechanisms, we assessed the function of the sperm …
insight into the underlying pathomechanisms, we assessed the function of the sperm …
3D structure and in situ arrangements of CatSper channel in the sperm flagellum
The sperm calcium channel CatSper plays a central role in successful fertilization as a
primary Ca2+ gateway. Here, we applied cryo-electron tomography to visualize the higher …
primary Ca2+ gateway. Here, we applied cryo-electron tomography to visualize the higher …
C2CD6 regulates targeting and organization of the CatSper calcium channel complex in sperm flagella
F Yang, M Gracia Gervasi, G Orta, DA Tourzani… - …, 2022 - journals.biologists.com
The CatSper cation channel is essential for sperm capacitation and male fertility. The multi-
subunit CatSper complexes form highly organized calcium signaling nanodomains on …
subunit CatSper complexes form highly organized calcium signaling nanodomains on …
A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking
Calcium signaling is critical for successful fertilization. In spermatozoa, calcium influx into the
sperm flagella mediated by the sperm-specific CatSper calcium channel is necessary for …
sperm flagella mediated by the sperm-specific CatSper calcium channel is necessary for …
The role of sperm membrane potential and ion channels in regulating sperm function
FM Pinto, A Odriozola, L Candenas… - International Journal of …, 2023 - mdpi.com
During the last seventy years, studies on mammalian sperm cells have demonstrated the
essential role of capacitation, hyperactivation and the acrosome reaction in the acquisition of …
essential role of capacitation, hyperactivation and the acrosome reaction in the acquisition of …
Sperm plasma membrane ion transporters and male fertility potential: A perspective under the prism of cryopreservation
Intracellular calcium homeostasis plays a crucial role in spermatozoa by regulating
physiological functions associated with sperm quality and male fertility potential. Intracellular …
physiological functions associated with sperm quality and male fertility potential. Intracellular …
High-throughput screening method for discovering CatSper inhibitors using membrane depolarization caused by external calcium chelation and fluorescent cell …
GM Luque, LJ Schiavi-Ehrenhaus… - Frontiers in Cell and …, 2023 - frontiersin.org
The exclusive expression of CatSper in sperm and its critical role in sperm function makes
this channel an attractive target for contraception. The strategy of blocking CatSper as a …
this channel an attractive target for contraception. The strategy of blocking CatSper as a …
Longitudinal Mapping of Personal Biotic and Abiotic Exposomes and Transcriptome in Underwater Confined Space Using Wearable Passive Samplers
Z Huang, C Peng, Z Rong, L Jiang, Y Li… - Environmental …, 2024 - ACS Publications
Silicone-based passive samplers, commonly paired with gas chromatography–mass
spectrometry (GC-MS) analysis, are increasingly utilized for personal exposure …
spectrometry (GC-MS) analysis, are increasingly utilized for personal exposure …